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Código: 042 IUIBS: Farmacología Molecular y Traslacional (BIOPharma)
Rama de Conocimiento
Ciencias de la Salud
Campo CNEAI
Ciencias Biomédicas
Datos de contacto
Departamento CIENCIAS CLÍNICAS
Dirección C/ Blas Cabrera Felipe s/n
Email leandrofco.fernandez@ulpgc.es
Web www.iuibs.ulpgc.es
Instituto Instituto Universitario de Investigaciones Biomédicas y Sanitarias
Palabras clave Farmacologia Preclinica, Química Médica, Immune - inflamación, Reposicionamiento, Receptor nuclear-Citocina
Key words Drug Discovery, Química Médica, Immuneinflamation, Drug repurposing, Nuclear Receptor-Cytokine
Miembros de Grupo de Investigación
Equipo de Investigación Equipo de Trabajo
FERNÁNDEZ PÉREZ, LEANDRO FCO (Coordinación) ARAGÓN SANCHEZ, JAVIER
CABRERA GALVÁN, JUAN JOSÉ CARDONA PAZ, ALEJANDRO
DÍAZ CHICO, BONIFACIO CLAVO VARAS, BERNARDINO
GUERRA HERNÁNDEZ, CARLOS BORJA DE LA ROSA MEDINA, JUAN VLADIMIR
LÓPEZ BLANCO, FÉLIX DÉNIZ CÁCERES, ANTONIO
MARTÍN RODRÍGUEZ, PATRICIA DÍAZ GONZÁLEZ, MARIO LORENZO
RECIO CRUZ, CARLOTA PILAR ESTÉVEZ BRAUN, ANA
RODRÍGUEZ GALLEGO, JOSE CARLOS FIUZA PÉREZ, Mª DOLORES
RODRÍGUEZ GALLEGO, JOSÉ CARLOS FLORES MORALES, AMILCAR
ROMERO ALEMÁN, MARÍA DEL MAR GALVÁN RUANO, ELIZABETH
TABRAUE TARBAY, CARLOS GARCÍA CASTELLANO, JOSÉ MANUEL
TABRAUE TARBAY, CARLOS GUILLÉN SALGADO, JOSÉ ANGEL
IGLESIAS GATO, DIEGO
MARTÍNEZ MARTÍN, MARÍA SOLEDAD
PANDIELLA ALONSO, ATANASIO
RAMIREZ MORENO, RAQUEL
SANTANA FERNÁNDEZ, YERAY
SANTANA RODRÍGUEZ, NORBERTO
SANTANA VIERA, SERGIO
Líneas de Investigación
Bioensayos en modelos celulares y animales de enfermedades humanas
Responsable: FERNÁNDEZ PÉREZ, LEANDRO FCO
Resumen: Laboratorio de cribado fenotípico o basado en dianas moleculares (receptores nucleares, cinasas, factores de transcripción). Análisis a tiempo real de la eficacia y toxicidad de pequeñas moléculas de nueva síntesis o medicamentos reposicionados en enfermedades raras.Modelos celulares 2D, 3D u organoides. Estudios de cinética y dosis-respuesta, a tiempo real sobre: proliferación celular, citotoxicidad, apoptosis, migración, invasión, metabolismo mitocondrial, angiogenesis, genes reporteros. fosforilación de proteínas. Sistema de análisis, de alto rendimiento Incucyte SX5 (hasta 6 placas de 96 pocillos, simultáneamente) de fenotipos celulares 2D, 3D u organoides. Modelos de enfermedades humanas en ratones modificados genéticamente: papel funcional de SOCS2 en enfermedades metabólicas (Diabetes tipo II, Diabetes Gestacional, trastornos de la gluconeogénesis y lipogénesis) o cáncer hepático. Modelos en roedores de NASH, Diabetes, Osteoporosis, Aterosclerosis, Hepatocarcinoma.
Summary: Phenotypic screening laboratory or based on molecular targets (nuclear receptors, kinases, transcription factors). Real-time analysis of the efficacy and toxicity of newly synthesized small molecules or repositioned drugs in rare diseases. 2D, 3D or organoid cell models. Kinetics and dose-response studies, in real time on: cell proliferation, cytotoxicity, apoptosis, migration, invasion, mitochondrial metabolism, angiogenesis, reporter genes. protein phosphorylation. High throughput analysis system, Incucyte SX5 (up to 6 96-well plates, simultaneously) of 2D, 3D or organoid cell phenotypes. Models of human diseases in genetically modified mice: functional role of SOCS2 in metabolic diseases (Type II Diabetes, Gestational Diabetes, disorders of gluconeogenesis and lipogenesis) or liver cancer. Non-genetically modified rodent models of NASH, Diabetes, Osteoporosis, Atherosclerosis, Hepatocarcinoma.
Descriptores: Bioensayos celulares, Receptores nucleares, Receptores estrógenos, Antagonistas estrogenicos, SERM, SERD
Keywords: Cellular Bioassays, Nuclear Receptors, Estrogen Receptors, Antiestrogens, SERM, SERD
Publicación1: Chemical-proteomics Identify Peroxiredoxin-1 as an Actionable Target in Triple-negative Breast Cancer
Publicación2: SOCS2 protects against chemical-induced hepatocellular carcinoma progression by modulating inflammation and cell proliferation in the liver
Publicación3: A novel naphthoquinone-coumarin hybrid that inhibits BCR-ABL1-STAT5 oncogenic pathway and reduces survival in imatinib-resistant chronic myelogenous leukemia cells
Publicación4: Lxr Signaling Regulates Macrophage Survival and Phenotype Polarization Response To Ionizing Radiation
Publicación5: Design, Semisynthesis, and Estrogenic Activity of Lignan Derivatives from Natural Dibenzylbutyrolactones
Biología Celular e Ingeniería de tejidos
Responsable: ROMERO ALEMÁN, MARÍA DEL MAR
Resumen: El procedimiento estrella para la regeneración de órganos y tejidos consiste en la sustitución de la zona dañada con trasplantes de células/tejidos autólogos y heterólogos. Sin embargo, éstos presentan importantes limitaciones como la reducida disponibilidad de los primeros y posibilidad de rechazo inmunológico de los últimos. Como alternativa, se ha propuesto el uso de materiales biocompatibles y biodegradables de origen natural y/o sintético que reproduzcan la organización microscópica natural de la matriz extracelular de los tejidos sanos y que provean de un microambiente óptimo para la adhesión, crecimiento, proliferación y diferenciación celular. Esta línea de investigación pretende utilizar los conocimientos básicos en el ámbito de la Biología Celular e Histología animal para diseñar el andamio que mejor simule la matriz extracelular del tejido/órgano diana (ej. matriz orientada para la regeneración de nervios periféricos; matriz no orientada para la regeneración de la piel) y testar su utilidad en la regeneración de tejidos con procedimientos in vitro e in vivo.
Publicación1: Hybrid Aloe Vera Nanofibres
Publicación2: Reactive macroglia provide living scaffolds for spontaneous axon regeneration in conditions of traumatic neuroma in the lizard optic nerve
Publicación3: Hybrid Honey Nanofibers
Citocinas y pie diabético - Patología de la glándula Tiroides - Hepatocarcinoma experimental
Responsable: CABRERA GALVÁN, JUAN JOSÉ
Resumen: Identificación de biomarcadores inmunológicos y genéticos asociados al pie diabético. Aplicación de técnicas bioquímicas y genéticas en la caracterización del proceso de curación del pie diabético. Patología de la Tiroides. Carcinoma hepatocelular..
Summary: Identification of immunological and genetic biomarkers associated with diabetic foot. Application of biochemical and genetic techniques in the characterization of the healing process of the diabetic foot. Thyroid Pathology. Hepatocellular carcinoma.
Publicación1: SOCS2 protects against chemical-induced hepatocellular carcinoma progression by modulating inflammation and cell proliferation in the liver
Publicación2: Thyroid fine needle aspiration, the Bethesda System and the BRAFV600E mutation in Papillary Thyroid Carcinoma. Association and prediction for biopsy.
Publicación3: TSH Level and Risk of Malignancy in Patients with Bethesda Category IV Thyroid Nodules
Publicación4: An effective algorithm to detect the possibility of being MSI phenotype in endometrial cancer given the BMI status and histological subtype: a statistical study
Publicación5: Adult-onset Alexander disease with a heterozygous D128N GFAP mutation: A pathological study
Drug Repurposing in orphan diseases.
Responsable: FERNÁNDEZ PÉREZ, LEANDRO FCO
Resumen: Reposicionamiento de fármacos en enfermedades raras. Resposicionamiento estatinas en el tratamiento del sarcoma.y cáncer hematológico.
Summary: Drug repurposing in rare diseases. Repositioning statins in the treatment of sarcomas and blood cancer. Drug repurposing aims to find existing EU or FDA-approved drugs for diseases. The basic idea of drug repurposing is to discover new useful activity for a distinct disease in an older clinically used drug or one that failed in later stages of development or disease develop resistance to drug. Our lab follow a drug repositioning strategy to identify advanced uses for statins (hipolipidemic drugs) and sarcomas. Front Oncol. 2021 Feb 25;11:626971.doi:10.3389/fonc.2021. Oncogene. 2019 Jun;38(24):4657-4668. doi: 10.1038/s41388-019-0752-3
Descriptores: Reposicionamiento, Estatinas, Sarcomas
Keywords: Drug repurposing, Statins, Sarcomas
Publicación1: Statins: Are Lipid-lowering Drugs Useful in Sarcomas?
Publicación2: The Mevalonate Pathway, a Metabolic Target in Cancer Therapy
Publicación3: Role of the IL-6/Jak/Stat Pathway in Tumor Angiogenesis: Influence of Estrogen Status
Publicación4: Chemical-proteomics Identify Peroxiredoxin-1 as an Actionable Target in Triple-negative Breast Cancer
Publicación5: Discovery of Highly Functionalized 5-hydroxy-2H-pyrrol-2-ones That Exhibit Antiestrogenic Effects in Breast and Endometrial Cancer Cells and Potentiate the Antitumoral Effect of Tamoxifen
Farmacocinética. Estudios de biodisponibilidad. Predicción ADMET
Responsable: FERNÁNDEZ PÉREZ, LEANDRO FCO
Resumen: Estudios de Farmacocinética. Biodisponibilidad. Predicción ADMET. Determinación de fármacos y metabolitos en muestras biológicas. Biodisponibilidad de nanoemulsiones..
Summary: Pharmacokinetic and bioavailability. ADMET. Determination of drugs and metabolites in biological samples. Development of drug-carrying nanoparticles.
Descriptores: Farmacocinética, ADMET, Biodisponibilidad, Nanoemulsion
Keywords: Pharmacokinetic, ADMET, Biodisponibility, Nanoemulsion
Publicación1: Design, Semisynthesis, and Estrogenic Activity of Lignan Derivatives from Natural Dibenzylbutyrolactones
Publicación2: Chemical-proteomics Identify Peroxiredoxin-1 as an Actionable Target in Triple-negative Breast Cancer
Publicación3: The Mevalonate Pathway, a Metabolic Target in Cancer Therapy
Publicación4: A novel naphthoquinone-coumarin hybrid that inhibits BCR-ABL1-STAT5 oncogenic pathway and reduces survival in imatinib-resistant chronic myelogenous leukemia cells
Publicación5: Modular Synthesis and Antiproliferative Activity of New Dihydro-1H-pyrazolo[1,3-b]pyridine Embelin Derivatives
Farmacodinámica. Bioensayos para la identificación de actividades moduladores de receptores nucleares en el contexto de enfermedades metabólicas y cáncer
Responsable: FERNÁNDEZ PÉREZ, LEANDRO FCO
Resumen: Nuestro laboratorio se ha especializado en procedimientos para para la identificación de nuevos moduladores de las actividades de receptores nucleares (ER, GR, AR, LXR). Estos se llevan a cabo mediante aproximaciones químicas altamente eficiente basada en el uso de estructuras privilegiadas a partir de fuentes naturales o mediante estrategias sintéticas eficaces, estudios de modelización 3D-QSAR y Docking. Estas estrategias han sido extensamente validadas por su eficacia para descubrir agonistas, antagonistas o agonistas/antagonistas mixtos, y sus aplicaciones en enfermedades metabólicas o cáncer relacionadas con receptores nucleares. Fenotipado preclínico en modelos celulares y animales. Usando estas estrategias, nuestro laboratorio ha identificado numerosas moléculas de pequeño tamaño con actividades agonistas y/o antagonistas de los Receptores de Estrógenos con potencial interés en Diabetes, esteatosis hepática, enfermedades inmunoinflamatorias o cancer hormono dependiente. Aplicamos estrategias farmaco-toxicogenómicas en modelos representativos de enfermedades humanas para caracterizar el mecanismo de acción y predecir la toxicidad de los nuevos productos antes de definir su eficacia y/o toxicidad en in vivo.
Summary: Our laboratory has specialized in procedures for the identification of new modulators of nuclear receptor activities (ER, GR, AR, LXR). These are done through a highly efficient chemical approaches based on the use of privileged structures from natural sources or through effective synthetic strategies, 3D-QSAR modeling studies and Docking. These strategies have been extensively validated for their effectiveness in discovering agonists, antagonists, or mixed agonists/antagonists, and their applications in metabolic diseases or cancer related to nuclear receptors. Preclinical phenotyping in cell and animal models. Using these strategies, our laboratory has identified numerous small molecules with agonist and/or antagonist activities of Estrogen Receptors with potential interest in Diabetes, hepatic steatosis, immunoinflammatory diseases or hormone-dependent cancer. We apply pharmaco-toxicogenomic strategies in a disease-based model to characterize the mechanism of action and predict the toxicity of new products before defining their efficacy and/or toxicity in vivo.
Descriptores: Quimica Médica, Cribado basado en fenotipo, Moleculas pequeño tamaño, Cribado basado en diana, SERM, SERD
Keywords: Medical Chemistry, Phenotypic-based screening, Small molecules, Target-based screening, SERM, SERD
Publicación1: Discovery of Highly Functionalized 5-hydroxy-2H-pyrrol-2-ones That Exhibit Antiestrogenic Effects in Breast and Endometrial Cancer Cells and Potentiate the Antitumoral Effect of Tamoxifen
Publicación2: Design, Semisynthesis, and Estrogenic Activity of Lignan Derivatives from Natural Dibenzylbutyrolactones
Publicación3: LXR Signaling Regulates Macrophage Survival and Inflammation in Response to Ionizing Radiation
Publicación4: Control of Liver Gene Expression by Sex Steroids and Growth Hormone Interplay
Publicación5: Signal transducer and activator of transcription (STAT)-5: an opportunity for drug development in oncohematology
Farmacodinámica. Bioensayos para la identificación de compuestos antitumorales-inhibidores de la via JAK-STAT-SOCS
Responsable: GUERRA HERNÁNDEZ, CARLOS BORJA
Resumen: Las proteínas de la familia STAT (Signal Transducer and Activator of Transcription) son esenciales para regular la expresión de genes necesarios para el crecimiento y metabolismo de la células en todas las etapas del desarrollo de los mamíferos. En contraposición, la activación aberrante de las proteínas STAT resulta en el desarrollo de tumores, enfermedades inmunológicas y metabólicas. Esto justifica que estas proteínas sean importantes dianas farmacológicas y que se demande la identificación de moduladores (inhibidores o activadores) de sus actividades biológicas. El objetivo que perseguimos en el presente proyecto es el descubrimiento y desarrollo de nuevas moléculas anti-STAT (1, 3, 5) con potencial actividad antitumoral y/o inmunomoduladora. Para ello estamos realizando la evaluación farmacológica de una quimioteca (librería química) que ha sido diseñada para la identificación de inhibidores de las proteínas Jak/Stat. Esto se lleva a cabo mediante una aproximación altamente eficiente basada en el uso de estructuras privilegiadas a partir de fuentes naturales o mediante estrategias sintéticas eficaces, estudios de modelización 3D-QSAR y Docking. Esta estrategia ha sido extensamente validada por su eficacia para descubrir fármacos más selectivos, potentes y menos tóxicos. La capacidad de estos productos para modificar las actividades transcripcionales dependientes de STAT se evalúa, en primer lugar, utilizando líneas celulares transfectadas con sistemas reporteros de luciferasa. Usando estas estrategias, nuestro laboratorio ha identificado nuevos fármacos inhibidores del crecimiento de células de cáncer humano dependientes de la vía STAT. Paralelamente, en este proyecto se evalúan las moléculas más activas en relación con respuestas biológicas concretas como proliferación, apoptosis, migración, invasión celular, respuesta inflamatoria, o formación de colonias tumorales. Aplicamos estrategias farmaco-toxicogenómicas de alta resolución para caracterizar con precisión los mecanismos moleculares de los nuevos fármacos. Estos estudios se complementan con la evaluación toxicológica, antitumoral o antiinflamatoria en modelos de animales in vivo.
Summary: The STAT (Signal Transducer and Activator of Transcription) family proteins are essential for regulating the expression of genes necessary for cell growth and metabolism at all stages of development in mammals. In contrast, aberrant activation of STAT proteins results in the development of tumors, immunological and metabolic diseases. This justifies that these proteins are important pharmacological targets and that the identification of modulators (inhibitors or activators) of their biological activities is demanded. The objective that we pursue in this project is the discovery and development of new anti-STAT (1, 3, 5) molecules with potential antitumor and/or immunomodulatory activity. For this, we are carrying out the pharmacological evaluation of a chemical library (chemical library) that has been designed for the identification of inhibitors of the Jak/Stat proteins. This is done through a highly efficient approach based on the use of privileged structures from natural sources or through effective synthetic strategies, 3D-QSAR modeling studies and Docking. This strategy has been extensively validated for its effectiveness in discovering more selective, potent, and less toxic drugs. The ability of these products to modify STAT-dependent transcriptional activities is first assessed using cell lines transfected with luciferase reporter systems. Using these strategies, our laboratory has identified new drugs that inhibit the growth of human cancer cells dependent on the STAT pathway. In parallel, this project evaluates the most active molecules in relation to specific biological responses such as proliferation, apoptosis, migration, cell invasion, inflammatory response, or formation of tumor colonies. We apply high-resolution pharmaco-toxicogenomic strategies to accurately characterize the molecular mechanisms of new drugs. These studies are complemented by toxicological, antitumor or anti-inflammatory evaluation in in vivo animal models.
Descriptores: STAT3/STAT5, Diana molecular, Moduladores multiquinasa, Antitumorales, SERM, SERD
Keywords: STAT3/STAT5, Drug Targets, Multikinase modulators, Antitumoral drugs, SERM, SERD
Publicación1: Chemical-proteomics Identify Peroxiredoxin-1 as an Actionable Target in Triple-negative Breast Cancer
Publicación2: JKST6, a novel multikinase modulator of the BCR-ABL1/STAT5 signaling pathway that potentiates direct BCR-ABL1 inhibition and overcomes imatinib resistance in chronic myelogenous leukemia
Publicación3: Design, Semisynthesis, and Estrogenic Activity of Lignan Derivatives from Natural Dibenzylbutyrolactones
Publicación4: The Mevalonate Pathway, a Metabolic Target in Cancer Therapy
Publicación5: Modular Synthesis and Antiproliferative Activity of New Dihydro-1H-pyrazolo[1,3-b]pyridine Embelin Derivatives
Farmacogenómica aplicada al descubrimiento y desarrollo de fármacos. DNA Microarrays (Plataforma Agilent) Bioinformática
Responsable: FERNÁNDEZ PÉREZ, LEANDRO FCO
Resumen: El laboratorio de Genómica del IUIBS dispone de una plataforma Agilent para el análisis de microarreglos de ADN que se ofrece a la comunidad científica de nuestro entorno académico y empresarial. La Fármaco-Toxicogenómica, definida como el estudio dinámico del transcriptoma y sus elementos regulatorios aplicado al descubrimiento del mecanismo de acción y toxicidad de los fármacos. En nuestro laboratorio disponemos de una Unidad de Genómica Funcional para abordar el estudio de la expresión de los genes, gran escala, en modelos temporales o dosis-dependientes. Esto ha permitido crear bases de datos extensas que están siendo usadas para descifrar las vías de señalización e identificar nuevos biomarcadores y dianas farmacológicas. Los biomarcadores que emergen de estos estudios pueden tener un valor pronóstico y pueden ser usados para predecir los resultados terapéuticos y la toxicidad de un fármaco. Esta aproximación metodológica, se está mostrando muy útil para acortar el tiempo de I+D+i+t de un fármaco, facilitar la identificación de combinaciones de medicamentos más potentes y menos tóxicas.
Summary: The IUIBS Genomics laboratory has an Agilent platform for the analysis of DNA microarrays that is offered to the scientific community of our academic and business environment. Pharmaco-Toxicogenomics, defined as the dynamic study of the transcriptome and its regulatory elements applied to the discovery of the mechanism of action and toxicity of drugs. In our laboratory we have a Functional Genomics Unit to address the study of gene expression, on a large scale, in temporal or dose-dependent models. This has allowed the creation of extensive databases that are being used to decipher signaling pathways and identify new biomarkers and drug targets. The biomarkers that emerge from these studies may have prognostic value and can be used to predict therapeutic outcomes and drug toxicity. This methodological approach is proving to be very useful for shortening the R+D+i+t time of a drug, facilitating the identification of more potent and less toxic drug combinations.
Descriptores: Genómica funcional, Expresión diferencial, Farmacogenómica
Keywords: Functional Genomic, Differential gene expression, Pharmacogenomic
Publicación1: Transcriptomic and lipidomic profiling reveals a functional interplay between sex steroids and growth hormone in the liver
Publicación2: Chemical-proteomics Identify Peroxiredoxin-1 as an Actionable Target in Triple-negative Breast Cancer
Publicación3: Synthesis and biological evaluation of novel inhibitors of signal transductor and activator of transcription (STAT) proteins in hematological malignances
Publicación4: JKST6, a novel multikinase modulator of the BCR-ABL1/STAT5 signaling pathway that potentiates direct BCR-ABL1 inhibition and overcomes imatinib resistance in chronic myelogenous leukemia
Publicación5: Control of Liver Gene Expression by Sex Steroids and Growth Hormone Interplay
Farmacología experimental en modelos de enfermedades metabólicas-inmunoinflamatorias (aterosclerosis, diabetes, cáncer). Moduladores de la respuesta inmune.
Responsable: RECIO CRUZ, CARLOTA PILAR
Descriptores: Macrófago, inmuno-inflamación, SOCS2, enfermedades hepáticas, ateroescleresosis-Diabetes
Keywords: Macrophage, inmuno-inflammatory, SOCS2, liver diseases, atherosclerosis-Diabetes
Publicación1: The Mevalonate Pathway, a Metabolic Target in Cancer Therapy
Publicación2: SOCS2 protects against chemical-induced hepatocellular carcinoma progression by modulating inflammation and cell proliferation in the liver
Publicación3: Galectin-9: A novel promoter of atherosclerosis progression
Publicación4: JKST6, a novel multikinase modulator of the BCR-ABL1/STAT5 signaling pathway that potentiates direct BCR-ABL1 inhibition and overcomes imatinib resistance in chronic myelogenous leukemia
Publicación5: Discovery of Highly Functionalized 5-hydroxy-2H-pyrrol-2-ones That Exhibit Antiestrogenic Effects in Breast and Endometrial Cancer Cells and Potentiate the Antitumoral Effect of Tamoxifen
I+D en Farmacología aplicada a Oncología
Responsable: DÍAZ CHICO, BONIFACIO
Resumen: Identificación de nuevas moléculas de pequeño tamaño con interés biomédico en Oncología. Descubrimiento de fármacos. Evaluación farmacológica y toxicológica preclínico. Farmacología Traslacional y empresa.
Summary: Identification of new small molecules with biomedical interest in Oncology. Drug discovery. Preclinical pharmacological and toxicological evaluation. Translational pharmacology and company. Mol Cell Biol. 2019, 15;39(5):e00376-18. doi: 10.1128/MCB.00376-18. Front Pharmacol. 2019, 9:1546.doi: 10.3389/fphar.2018.01546. Oncotarget. 2017, 8(18):29679-29698.doi: 10.18632/oncotarget.11425.
Publicación1: Chemical-proteomics Identify Peroxiredoxin-1 as an Actionable Target in Triple-negative Breast Cancer
Publicación2: A novel naphthoquinone-coumarin hybrid that inhibits BCR-ABL1-STAT5 oncogenic pathway and reduces survival in imatinib-resistant chronic myelogenous leukemia cells
Publicación3: Common and differential transcriptional actions of nuclear receptors liver X receptors ¿ and ß in macrophages
Publicación4: Androgen receptor gene polymorphisms and maximal fat oxidation in healthy men. A longitudinal study
Receptor nuclear LXR - Fisiopatología del macrófago
Responsable: CASTRILLO VIGUERA, ANTONIO JESÚS
Publicación1: Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB
Publicación2: A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart
Publicación3: LXR Signaling Regulates Macrophage Survival and Inflammation in Response to Ionizing Radiation
Publicación4: Nuclear receptors: Lipid and hormone sensors with essential roles in the control of cancer development
Publicación5: Analysis of LXR nuclear receptor cistrome through ChIP-Seq data bioinformatics
Proyecto1: Alteración De La Actividad De LXR En Macrófagos Durante La Inflamación
Receptor nuclear LXR - inflamacion, cáncer
Responsable: TABRAUE TARBAY, CARLOS
Publicación1: Crosstalk between LXR and caveolin-1 signaling supports cholesterol efflux and anti-inflammatory pathways in macrophages
Publicación2: LXR Signaling Regulates Macrophage Survival and Inflammation in Response to Ionizing Radiation
Publicación3: Analysis of LXR nuclear receptor cistrome through ChIP-Seq data bioinformatics
Publicación4: Bone marrow-derived macrophage immortalization of LXR nuclear receptor-deficient cells
Publicación5: Common and differential transcriptional actions of nuclear receptors liver X receptors ¿ and ß in macrophages
Título Revista/Libro ISSN/ISBN Impacto Citas Año
Chemical-proteomics Identify Peroxiredoxin-1 as an Actionable Target in Triple-negative Breast Cancer International Journal of Biological Sciences 1449-2288 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2023
Epigenome profiling reveals aberrant DNA methylation signature in GATA2 deficiency Haematologica 0390-6078 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2023
Flavonoid Derivative FMC, as a Potent Cytotoxic and Apoptosis Inducer in Several Human Cancer Cell Lines WOS: 0, Scopus: 0 2023
Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia Journal of Experimental Medicine 0022-1007 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2023
Immunometabolic actions of trabectedin and lurbinectedin on human macrophages: relevance for their anti-tumor activity Frontiers in Immunology 1664-3224 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2023
Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB Cellular and Molecular Life Sciences 1420-682X JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 1 2023
Relaciones estructura-actividad de 1,3-difenilpropenonas revelan un potente inhibidor de la polimerización de tubulina WOS: 0, Scopus: 0 2023
The Effect of Honey, Aloe Vera, and Hydrocolloid Dressing on the Healing Process of Murine Excisional Wounds International Journal of Lower Extremity Wounds 1534-7346 JCR‑Q3; SJR‑Q3; SCIE WOS: 0, Scopus: 0 2023
Thyroid fine needle aspiration, the Bethesda System and the BRAFV600E mutation in Papillary Thyroid Carcinoma. Association and prediction for biopsy. Acta cytologica 0001-5547 JCR‑Q3; SJR‑Q2; SCIE WOS: 0, Scopus: 1 2023
Activation of LXR Nuclear Receptors Impairs the Anti-Inflammatory Gene and Functional Profile of M-CSF-Dependent Human Monocyte-Derived Macrophages Frontiers in Immunology 1664-3224 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 6 2022
An effective algorithm to detect the possibility of being MSI phenotype in endometrial cancer given the BMI status and histological subtype: a statistical study Clinical and Translational Oncology 1699-048X JCR‑Q3; SJR‑Q2; SCIE WOS: 0, Scopus: 0 2022
Autoantibodies against type I IFNs in patients with critical influenza pneumonia Journal of Experimental Medicine 0022-1007 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 23 2022
Body composition and effect of insulin treatment during pregnancy in Socs2(-/-) mice with gestational diabetes and macrosomia Diabetologia (Berlin) 0012-186X JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2022
Design, Semisynthesis, and Estrogenic Activity of Lignan Derivatives from Natural Dibenzylbutyrolactones Pharmaceuticals 1424-8247 JCR‑Q1; SJR‑Q1; ESCI WOS: 0, Scopus: 0 2022
Discovery of Highly Functionalized 5-hydroxy-2H-pyrrol-2-ones That Exhibit Antiestrogenic Effects in Breast and Endometrial Cancer Cells and Potentiate the Antitumoral Effect of Tamoxifen Cancers (Basel) 2072-6694 JCR‑Q1; SJR‑Q1 WOS: 0, Scopus: 1 2022
Galectin-9: A novel promoter of atherosclerosis progression Atherosclerosis 0021-9150 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 2 2022
High-fat diet activates splenic NOD1 and enhances neutrophil recruitment and neutrophil extracellular traps release in the spleen of ApoE-deficient mice Cellular and Molecular Life Sciences 1420-682X JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 5 2022
Hybrid Aloe Vera Nanofibres Oficina Europea de Patentes WOS: 0, Scopus: 0 2022
La interacción de las galectinas-1, -3 y -9 en la respuesta inmunoinflamatoria subyacente a las enfermedades cardiovasculares y metabólicas Cardiovascular Diabetology 1475-2840 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 5 2022
NOD1 splenic activation confers ferroptosis protection and reduces macrophage recruitment under pro-atherogenic conditions Biomedicine and Pharmacotherapy 0753-3322 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 13 2022
Título Revista/Libro ISSN/ISBN Impacto Citas Año
Role of the IL-6/Jak/Stat Pathway in Tumor Angiogenesis: Influence of Estrogen Status WOS: 0, Scopus: 0 2022
SOCS2 protects against chemical-induced hepatocellular carcinoma progression by modulating inflammation and cell proliferation in the liver Biomedicine and Pharmacotherapy 0753-3322 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 2 2022
Statins: Are Lipid-lowering Drugs Useful in Sarcomas? WOS: 0, Scopus: 0 2022
Structure-activity relationships reveal a 2-furoyloxychalcone as a potent cytotoxic and apoptosis inducer for human U-937 and HL-60 leukaemia cells Bioorganic Chemistry 0045-2068 JCR‑Q1; SJR‑Q2; SCIE WOS: 0, Scopus: 2 2022
Unraveling the interplay between iron homeostasis, ferroptosis and extramedullary hematopoiesis Pharmacological Research 1043-6618 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 4 2022
Alpha-1 antitrypsin deficiency hidden in allegedly normal variants Journal of Asthma 0277-0903 SJR‑Q2; SCIE WOS: 0, Scopus: 0 2021
Challenges in understanding host genetics and severity of community-acquired pneumonia ERJ Open Research 2312-0541 JCR‑Q2; SJR‑Q2 WOS: 0, Scopus: 0 2021
Crosstalk between LXR and caveolin-1 signaling supports cholesterol efflux and anti-inflammatory pathways in macrophages Frontiers in Endocrinology 1664-2392 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 9 2021
JKST6, a novel multikinase modulator of the BCR-ABL1/STAT5 signaling pathway that potentiates direct BCR-ABL1 inhibition and overcomes imatinib resistance in chronic myelogenous leukemia Biomedicine and Pharmacotherapy 0753-3322 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 4 2021
Modular Synthesis and Antiproliferative Activity of New Dihydro-1H-pyrazolo[1,3-b]pyridine Embelin Derivatives Pharmaceuticals 1424-8247 JCR‑Q1; SJR‑Q1; ESCI WOS: 0, Scopus: 0 2021
Modulation by Ozone Therapy of Oxidative Stress in Chemotherapy-Induced Peripheral Neuropathy: The Background for a Randomized Clinical Trial International Journal of Molecular Sciences 1661-6596 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 12 2021
Nuclear receptors: Lipid and hormone sensors with essential roles in the control of cancer development Seminars in Cancer Biology 1044-579X JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 21 2021
Pseudomembranous Tracheobronchitis in an Immunocompetent Patient Open Respiratory Archives 2659-6636 WOS: 0, Scopus: 0 2021
The Mevalonate Pathway, a Metabolic Target in Cancer Therapy Frontiers in Oncology 2234-943X JCR‑Q2; SJR‑Q1; SCIE WOS: 0, Scopus: 53 2021
A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart Cell 0092-8674 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 1 2020
Análisis comparativo de la satisfacción del estudiantado con la docencia del área de Biología Celular antes y después de la introducción del EEES WOS: 0, Scopus: 0 2020
Characterisation of endogenous Galectin-1 and -9 expression in monocyte and macrophage subsets under resting and inflammatory conditions Biomedicine and Pharmacotherapy 0753-3322 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2020
Contribution of Extramedullary Hematopoiesis to Atherosclerosis. The Spleen as a Neglected Hub of Inflammatory Cells Frontiers In Immunology 1664-3224 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 20 2020
NOD1 deficiency promotes an imbalance of thyroid hormones and microbiota homeostasis in mice fed high fat diet Scientific Reports 2045-2322 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 14 2020
Should MASP-2 Deficiency Be Considered a Primary Immunodeficiency? Relevance of the Lectin Pathway Journal of Clinical Immunology 0271-9142 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 14 2020
Título Revista/Libro ISSN/ISBN Impacto Citas Año
Stress erythropoiesis in atherogenic mice Scientific Reports 2045-2322 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 3 2020
TSH Level and Risk of Malignancy in Patients with Bethesda Category IV Thyroid Nodules Hormones and Cancer 1868-8497 JCR‑Q3; SJR‑Q2; SCIE WOS: 0, Scopus: 0 2020
A Biased Agonist at Immunometabolic Receptor GPR84 Causes Distinct Functional Effects in Macrophages ACS Chemical Biology 1554-8929 JCR‑Q2; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2019
A novel naphthoquinone-coumarin hybrid that inhibits BCR-ABL1-STAT5 oncogenic pathway and reduces survival in imatinib-resistant chronic myelogenous leukemia cells Frontiers in Pharmacology 1663-9812 JCR‑Q1; SJR‑Q1; SCIE WOS: 6, Scopus: 8 2019
Adult-onset Alexander disease with a heterozygous D128N GFAP mutation: A pathological study Histology and Histopathology 0213-3911 JCR‑Q3; SJR‑Q2; SCIE WOS: 3, Scopus: 3 2019
Analysis of LXR nuclear receptor cistrome through ChIP-Seq data bioinformatics Methods in molecular biology (Clifton, N.J.) 1064-3745 SJR‑Q3 WOS: 0, Scopus: 2 2019
Bone marrow-derived macrophage immortalization of LXR nuclear receptor-deficient cells Methods in molecular biology (Clifton, N.J.) 1064-3745 SJR‑Q3 WOS: 0, Scopus: 3 2019
Common and differential transcriptional actions of nuclear receptors liver X receptors ¿ and ß in macrophages Molecular and Cellular Biology 0270-7306 JCR‑Q2; SJR‑Q1; SCIE WOS: 24, Scopus: 34 2019
Control of Liver Gene Expression by Sex Steroids and Growth Hormone Interplay WOS: 0, Scopus: 0 2019
DEL-1 promotes macrophage efferocytosis and clearance of inflammation Nature Immunology 1529-2908 JCR‑Q1; SJR‑Q1; SCIE WOS: 105, Scopus: 140 2019
Glucose meters in diabetes research: accuracy evaluation of portable blood glucose meters in mice Diabetologia (Berlin) 0012-186X JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2019
Hybrid electrospun PHBV/Aloe vera and PHBV/Honey nanofibers are scaffolds for rat dorsal root ganglion neurite outgrowth and guidance as well as for the regeneration of mouse skin after wounding. GLIA 0894-1491 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2019
JAK, an Oncokinase in Hematological Cancer WOS: 0, Scopus: 0 2019
LXR Signaling Regulates Macrophage Survival and Inflammation in Response to Ionizing Radiation International Journal of Radiation Oncology Biology Physics 0360-3016 JCR‑Q1; SJR‑Q1; SCIE WOS: 12, Scopus: 17 2019
Lxr Signaling Regulates Macrophage Survival and Phenotype Polarization Response To Ionizing Radiation Radiotherapy and Oncology 0167-8140 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2019
Modulation of oxidative stress by ozone therapy in the prevention and treatment of chemotherapy-induced toxicity: Review and prospects Antioxidants 2076-3921 JCR‑Q1; SJR‑Q1; SCIE WOS: 32, Scopus: 54 2019
Signal transducer and activator of transcription (STAT)-5: an opportunity for drug development in oncohematology Oncogene 0950-9232 JCR‑Q1; SJR‑Q1; SCIE WOS: 23, Scopus: 26 2019
Students satisfaction with teaching of histology before and after the adaptation to the European Higher Education Area in the ULPGC Histology and Histopathology 1699-5848 SJR‑Q2; SCIE WOS: 0, Scopus: 0 2019
SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity Nature Immunology 1529-2908 JCR‑Q1; SJR‑Q1; SCIE WOS: 90, Scopus: 138 2019
Synthesis and antiplasmodial activity of 1,2,3-triazole-naphthoquinone conjugates Molecules 1420-3049 JCR‑Q2; SJR‑Q1; SCIE WOS: 10, Scopus: 18 2019
Título Revista/Libro ISSN/ISBN Impacto Citas Año
Synthesis, characterization and antiproliferative activity of mixed ligand complexes of Cu2+ and Co2+ with lapachol Polyhedron 0277-5387 JCR‑Q2; SJR‑Q2; SCIE WOS: 4, Scopus: 5 2019
Activation of the Immune-Metabolic Receptor GPR84 Enhances Inflammation and Phagocytosis in Macrophages Frontiers in Immunology 1664-3224 JCR‑Q2; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2018
Acute coronary syndrome: An ideal scenario for direct Absorb implantation? Kardiologia Polska 0022-9032 JCR‑Q3; SJR‑Q3; SCIE WOS: 0, Scopus: 0 2018
Alpha 1 antitrypsin distribution in an allergic asthmatic population sensitized to house dust mites Clinical and Translational Allergy 2045-7022 JCR‑Q2; SJR‑Q1; SCIE WOS: 10, Scopus: 16 2018
Correction: CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia [Oncotarget, 8 (2017) (29679-29698)] Doi: 10.18632/oncotarget.11425 Oncotarget 1949-2553 SJR‑Q1 WOS: 0, Scopus: 0 2018
Disrupting lxr¿ phosphorylation promotes foxm1 expression and modulates atherosclerosis by inducing macrophage proliferation Proceedings of the National Academy of Sciences of the United States of America 0027-8424 JCR‑Q1; SJR‑Q1; SCIE WOS: 32, Scopus: 31 2018
Eccrine sweat glands associate with the human hair follicle within a defined compartment of dermal white adipose tissue British journal of dermatology (1951. Print) 0007-0963 JCR‑Q1; SJR‑Q1; SCIE WOS: 28, Scopus: 30 2018
Elaboración de rúbricas para la evaluación de competencias prácticas en un laboratorio de Ciencias Médicas WOS: 0, Scopus: 0 2018
Epidemiological study of the allergic population in the north of Gran Canaria Journal of Investigational Allergology and Clinical Immunology 1018-9068 JCR‑Q2; SJR‑Q3; SCIE WOS: 2, Scopus: 2 2018
EP-2333: NK and B cells are novel prognostic factors for disease free survival in cervical carcinoma patients Radiotherapy and Oncology 0167-8140 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2018
In Vitro Migration Assays WOS: 0, Scopus: 0 2018
Incomplete penetrance for isolated congenital asplenia in humans with mutations in translated and untranslated RPSA exons Proceedings of the National Academy of Sciences of the United States of America 0027-8424 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 30 2018
Laboratory evaluation of the IFN-¿ circuit for the molecular diagnosis of Mendelian susceptibility to mycobacterial disease Critical Reviews in Clinical Laboratory Sciences 1040-8363 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 40 2018
Lawsone, juglone, and ß-Lapachone derivatives with enhanced mitochondrial-based toxicity ACS Chemical Biology 1554-8929 JCR‑Q1; SJR‑Q1; SCIE WOS: 24, Scopus: 27 2018
Lethal influenza in two related adults with inherited GATA2 deficiency Journal of Clinical Immunology 0271-9142 JCR‑Q2; SJR‑Q2; SCIE WOS: 24, Scopus: 24 2018
Liver X receptor nuclear receptors are transcriptional regulators of dendritic cell chemotaxis Molecular and Cellular Biology 0270-7306 JCR‑Q2; SJR‑Q1; SCIE WOS: 13, Scopus: 23 2018
Novel naphthoquinone-coumarin hybrids as inhibitors of BCR-ABL-STAT5 signaling pathway in chronic myelogenous leukemia Basic and Clinical Pharmacology and Toxicology 1742-7835 JCR‑Q3; SJR‑Q2; SCIE WOS: 0, Scopus: 0 2018
Nrf2 Activation Provides Atheroprotection in Diabetic Mice Through Concerted Upregulation of Antioxidant, Anti-inflammatory, and Autophagy Mechanisms Frontiers in Pharmacology 1663-9812 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2018
Origin and specialization of splenic macrophages Cellular immunology (Print) 0008-8749 JCR‑Q2; SJR‑Q2; SCIE WOS: 37, Scopus: 41 2018
Outbreak and eradication of tropical rat mite (Acari: Macronyssidae) in a European animal facility Journal of Medical Entomology 0022-2585 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 2 2018
Título Revista/Libro ISSN/ISBN Impacto Citas Año
Phenalenone-photodynamic therapy induces apoptosis on human tumor cells mediated by caspase-8 and p38-MAPK activation Molecular Carcinogenesis 0899-1987 JCR‑Q2; SJR‑Q2; SCIE WOS: 22, Scopus: 25 2018
Primary immunodeficiency diseases in lung disease: warning signs, diagnosis and management Respiratory Research 1465-9921 JCR‑Q2; SJR‑Q1; SCIE WOS: 0, Scopus: 26 2018
Satisfacción de los estudiantes con la docencia en las asignaturas del área de Biología Celular WOS: 0, Scopus: 0 2018
Skeletal muscle pyruvate dehydrogenase phosphorylation and lactate accumulation during sprint exercise in normoxia and severe acute hypoxia: effects of antioxidants Frontiers in Physiology 1664-042X JCR‑Q2; SJR‑Q2; SCIE WOS: 12, Scopus: 15 2018
SOCS1-targeted therapy ameliorates renal and vascular oxidative stress in diabetes via STAT1 and PI3K inhibition Laboratory Investigation 0023-6837 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2018
The activin A-peroxisome proliferator-activated receptor gamma axis contributes to the transcriptome of GM-CSF-conditioned human macrophages Frontiers in Immunology 1664-3224 JCR‑Q2; SJR‑Q1; SCIE WOS: 12, Scopus: 13 2018
The Role of Metabolite-Sensing G Protein-Coupled Receptors in Inflammation and Metabolic Disease Antioxidants and Redox Signaling 1523-0864 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2018
Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA Nature Medicine 1078-8956 JCR‑Q1; SJR‑Q1; SCIE WOS: 148, Scopus: 160 2018
Transcriptomic and lipidomic profiling reveals a functional interplay between sex steroids and growth hormone in the liver FEBS Open Bio 2211-5463 JCR‑Q4; SJR‑Q2; SCIE WOS: 0, Scopus: 0 2018
Absence of the Non-Signalling Chemerin Receptor CCRL2 Exacerbates Acute Inflammatory Responses In Vivo Frontiers in Immunology 1664-3224 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2017
Aloe vera gel and hybrid nanofibers are permissive substrates for neurite outgrowth Histology and Histopathology 0213-3911 JCR‑Q3; SJR‑Q2; SCIE WOS: 0, Scopus: 0 2017
Androgen receptor gene polymorphisms and maximal fat oxidation in healthy men. A longitudinal study Nutrición Hospitalaria 0212-1611 JCR‑Q4; SJR‑Q3; SCIE WOS: 4, Scopus: 10 2017
Cannabinoid Receptor 2 Modulates Neutrophil Recruitment in a Murine Model of Endotoxemia Mediators of Inflammation 0962-9351 JCR‑Q2; SJR‑Q2; SCIE WOS: 0, Scopus: 0 2017
CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia Oncotarget 1949-2553 SJR‑Q1 WOS: 7, Scopus: 10 2017
Fungal pattern receptors down-regulate the inflammatory response by a cross-inhibitory mechanism independent of interleukin-10 production Immunology 0019-2805 JCR‑Q2; SJR‑Q1; SCIE WOS: 10, Scopus: 10 2017
In vitro activity of 1H-phenalen-1-one derivatives against Acanthamoeba castellanii Neff and their mechanisms of cell death Experimental parasitology 0014-4894 JCR‑Q3; SJR‑Q2; SCIE WOS: 7, Scopus: 7 2017
Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP eLife 2050-084X JCR‑Q1; SJR‑Q1; SCIE WOS: 28, Scopus: 40 2017
Interplay between HSP90 and Nrf2 pathways in diabetes-associated atherosclerosis Clinica e Investigacion en Arteriosclerosis 0214-9168 SJR‑Q3; ESCI WOS: 0, Scopus: 0 2017
MAFB determines human macrophage anti-inflammatory polarization: relevance for the pathogenic mechanisms operating in multicentric carpotarsal osteolysis Journal of Immunology 0022-1767 JCR‑Q2; SJR‑Q1; SCIE WOS: 39, Scopus: 40 2017
Nogo-A does not inhibit retinal axon regeneration in the lizard Gallotia galloti Journal of Comparative Neurology 0021-9967 JCR‑Q1; SJR‑Q1; SCIE WOS: 5, Scopus: 6 2017
Título Revista/Libro ISSN/ISBN Impacto Citas Año
Ozone therapy protects against rejection in a lung transplantation model: a new treatment? The annals of thoracic surgery 0003-4975 JCR‑Q1; SJR‑Q1; SCIE WOS: 4, Scopus: 7 2017
Phagocytosis imprints heterogeneity in tissue-resident macrophages Journal of Experimental Medicine 0022-1007 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 182 2017
Skeletal muscle signaling, metabolism, and performance during sprint exercise in severe acute hypoxia after the ingestion of antioxidants Journal of Applied Physiology 8750-7587 JCR‑Q1; SJR‑Q1; SCIE WOS: 11, Scopus: 12 2017
SOCS2 Mouse as a potential model of macrosomia and gestational diabetes WOS: 0, Scopus: 0 2017
Suppressor of Cytokine Signaling-1 Peptidomimetic Limits Progression of Diabetic Nephropathy Journal of the American Society of Nephrology : JASN 1046-6673 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2017
Synthesis and biological evaluation of novel inhibitors of signal transductor and activator of transcription (STAT) proteins in hematological malignances Basic and Clinical Pharmacology and Toxicology 1742-7835 JCR‑Q2; SJR‑Q2; SCIE WOS: 0, Scopus: 0 2017
The nuclear receptor LXR limits bacterial infection of host macrophages through a mechanism that impacts cellular NAD metabolism Cell Reports 2211-1247 JCR‑Q1; SJR‑Q1; SCIE WOS: 72, Scopus: 71 2017
The Potential Therapeutic Application of Peptides and Peptidomimetics in Cardiovascular Disease Frontiers in Pharmacology 1663-9812 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2017
5-Ethynylarylnaphthalimides as antitumor agents: synthesis and biological evaluation Bioorganic and Medicinal Chemistry 0968-0896 JCR‑Q2; SJR‑Q1; SCIE WOS: 7, Scopus: 7 2017
Acute exposure to apolipoprotein A1 inhibits macrophage chemotaxis in vitro and monocyte recruitment in vivo eLife 2050-084X JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2016
Androgen receptor gene polymorphism influence fat accumulation: a longitudinal study from adolescence to adult age Scandinavian Journal of Medicine and Science in Sports 0905-7188 JCR‑Q1; SJR‑Q1; SCIE WOS: 12, Scopus: 16 2016
Association between single-nucleotide polymorphisms in DNA double-strand break repair genes and prostate cancer aggressiveness in the Spanish population Prostate Cancer and Prostatic Diseases 1365-7852 JCR‑Q1; SJR‑Q1; SCIE WOS: 13, Scopus: 14 2016
Autoevaluación en una experiencia de trabajo colaborativo en la Universidad WOS: 0, Scopus: 0 2016
Cholesterol accumulation in CD11c+ immune cells is a causal and targetable factor in autoimmune disease Immunity 1074-7613 JCR‑Q1; SJR‑Q1; SCIE WOS: 43, Scopus: 74 2016
Direct bioresorbable vascular scaffold implantation: Feasibility and midterm results Catheterization and Cardiovascular Interventions 1522-1946 JCR‑Q2; SJR‑Q1; SCIE WOS: 9, Scopus: 10 2016
Effect of regional muscle location but not adiposity on mitochondrial biogenesis-regulating proteins European Journal of Applied Physiology 1439-6319 JCR‑Q2; SJR‑Q1; SCIE WOS: 3, Scopus: 3 2016
Evaluación farmacológica preclínica de nuevos productos bioactivos con aplicaciones como anti-tumorales WOS: 0, Scopus: 0 2016
Gain-of-function mutation in PIK3R1 in a patient with a narrow clinical phenotype of respiratory infections Clinical Immunology 1521-6616 JCR‑Q2; SJR‑Q1; SCIE WOS: 0, Scopus: 15 2016
Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype Blood 0006-4971 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 374 2016
IFITM3 and severe influenza virus infection. No evidence of genetic association European Journal of Clinical Microbiology and Infectious Diseases 0934-9723 JCR‑Q2; SJR‑Q1; SCIE WOS: 30, Scopus: 29 2016
Título Revista/Libro ISSN/ISBN Impacto Citas Año
Patency of coronary side branches covered by an everolimus-eluting bioresorbable vascular scaffold: clinical outcomes and computed tomography scan follow-up EuroIntervention 1774-024X JCR‑Q1; SJR‑Q1; SCIE WOS: 8, Scopus: 9 2016
Preface to special issue on "hormones and Diabetes" Hormone Molecular Biology and Clinical Investigation 1868-1883 ESCI WOS: 0, Scopus: 0 2016
Sex steroids and growth hormone interactions Endocrinología y Nutrición 1575-0922 JCR‑Q4 WOS: 6, Scopus: 8 2016
Suppressor of cytokine signaling 2 (SOCS2) deletion protects against multiple low dose streptozotocin-induced type 1 diabetes in adult male mice Hormone Molecular Biology and Clinical Investigation 1868-1883 ESCI WOS: 6, Scopus: 5 2016
The nuclear receptor LXR modulates interleukin-18 levels in macrophages through multiple mechanisms Scientific Reports 2045-2322 JCR‑Q1; SJR‑Q1; SCIE WOS: 30, Scopus: 30 2016
Una experiencia de trabajo colaborativo en el Grado de Enfermería de la ULPGC WOS: 0, Scopus: 0 2016
A novel gain-of-function STAT1 mutation resulting in basal phosphorylation of STAT1 and increased distal IFN-¿-mediated responses in chronic mucocutaneous candidiasis Molecular Immunology 0161-5890 JCR‑Q2; SJR‑Q2; SCIE WOS: 0, Scopus: 18 2015
Altered profile of circulating endothelial-derived microparticles in ventilator-induced lung injury Critical Care Medicine 0090-3493 JCR‑Q1; SJR‑Q1; SCIE WOS: 23, Scopus: 26 2015
Androgen receptor CAG and GGN repeat polymorphisms and bone mass in boys and girls Nutrición Hospitalaria 0212-1611 JCR‑Q3; SJR‑Q1; SCIE WOS: 5, Scopus: 6 2015
Diagnostic and therapeutic challenges in a child with complete interferon-¿ receptor 1 deficiency Pediatric Blood and Cancer 1545-5009 JCR‑Q1; SJR‑Q1; SCIE WOS: 20, Scopus: 25 2015
Gene delivery of suppressors of cytokine signaling (SOCS) inhibits inflammation and atherosclerosis development in mice Basic Research in Cardiology 0300-8428 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2015
Genetic variations in genes involved in testosterone metabolism are associated with prostate cancer progression: A Spanish multicenter study Urologic Oncology: Seminars and Original Investigations 1078-1439 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 6 2015
High-grade astrocytoma (glioblastoma multiforme) in an Atlantic spotted dolphin (Stenella frontalis) Journal of Comparative Pathology 0021-9975 JCR‑Q2; SJR‑Q1; SCIE WOS: 7, Scopus: 7 2015
Intraethnic variation in steroid-5-alpha-reductase polymorphisms in prostate cancer patients: a potential factor implicated in 5-alpha-reductase inhibitor treatment Journal of Genetics 0022-1333 JCR‑Q4; SJR‑Q4; SCIE WOS: 1, Scopus: 2 2015
Monozygotic twins discordant for common variable immunodeficiency reveal impaired DNA demethylation during naïve-to-memory B-cell transition Nature Communications 2041-1723 SJR‑Q1; SCIE WOS: 0, Scopus: 73 2015
Outcomes and computed tomography scan follow-up of bioresorbable vascular scaffold for the percutaneous treatment of chronic total coronary artery occlusion The American journal of cardiology 0002-9149 JCR‑Q2; SJR‑Q1; SCIE WOS: 35, Scopus: 38 2015
Peptide-based inhibition of I¿B kinase/nuclear factor-¿B pathway protects against diabetes-associated nephropathy and atherosclerosis in a mouse model of type 1 diabetes Diabetologia (Berlin) 0012-186X JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2015
Persistent infection by a mycobacterium tuberculosis strain that was theorized to have advantageous properties, as it was responsible for a massive outbreak Journal of Clinical Microbiology 0095-1137 JCR‑Q2; SJR‑Q1; SCIE WOS: 0, Scopus: 12 2015
Physical fitness, adiposity and testosterone concentrations are associated to playing position in professional basketballers Nutrición Hospitalaria 0212-1611 JCR‑Q3; SJR‑Q1; SCIE WOS: 6, Scopus: 15 2015
Single amino acid charge switch defines clinically distinct proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1)¿associated inflammatory diseases Journal of Allergy and Clinical Immunology 0091-6749 SJR‑Q1; SCIE WOS: 0, Scopus: 82 2015
Título Revista/Libro ISSN/ISBN Impacto Citas Año
Synthesis of 4,4¿-Diaminotriphenylmethanes with Potential Selective Estrogen Receptor Modulator (SERM)-like Activity ChemMedChem 1860-7179 JCR‑Q2; SJR‑Q1; SCIE WOS: 3, Scopus: 4 2015
Targeting HSP90 Ameliorates Nephropathy and Atherosclerosis Through Suppression of NF-¿B and STAT Signaling Pathways in Diabetic Mice Diabetes (New York, N.Y.) 0012-1797 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2015
The value of thyroperoxidase as a prognostic factor for differentiated thyroid cancer - A long-term follow-up study Thyroid Research 1756-6614 SJR‑Q3; ESCI WOS: 0, Scopus: 13 2015
Additional information on the role of histopathology in diagnosing diabetic foot osteomyelitis Diabetic Medicine 0742-3071 JCR‑Q2; SJR‑Q1; SCIE WOS: 0, Scopus: 6 2014
Anti-inflammatory actions of acanthoic acid-related diterpenes involve activation of the PI3K p110¿/¿ subunits and inhibition of NF-¿B Chemistry & biology WOS: 0, Scopus: 20 2014
Clinical and immunogenetic factors associated with pneumonia in patients with systemic lupus erythematosus: A case-control study Journal of Rheumatology 0315-162X JCR‑Q2; SJR‑Q2; SCIE WOS: 11, Scopus: 14 2014
Clinical features of candidiasis in patients with inherited interleukin 12 receptor ß1 deficiency Clinical Infectious Diseases 1058-4838 JCR‑Q1; SJR‑Q1; SCIE WOS: 68, Scopus: 94 2014
GLUT4 and Glycogen Synthase Are Key Players in Bed Rest-Induced Insulin Resistance (vol 61, pg 1090, 2012) Diabetes (New York, N.Y.) 0012-1797 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2014
Immediate Results and Long-Term Clinical Outcome of Patients With Unprotected Distal Left Main Restenosis The CORPAL Registry (Cordoba and Las Palmas) JACC: Cardiovascular Interventions 1936-8798 JCR‑Q1; SJR‑Q1; SCIE WOS: 11, Scopus: 14 2014
Immune effects of high dose radiation treatment: Implications of ionizing radiation on the development of bystander and abscopal effects Translational Cancer Research 2218-676X SCIE WOS: 0, Scopus: 53 2014
Indium catalyzed solvent-free multicomponent synthesis of cytotoxic dibenzo[a,h]anthracenes from aldehydes, 2-hydroxy-1,4-naphthoquinone, and 2-naphthol Tetrahedron 0040-4020 JCR‑Q2; SJR‑Q1; SCIE WOS: 16, Scopus: 19 2014
Influence of age on leptin induced skeletal muscle signalling Acta Physiologica 1748-1708 JCR‑Q1; SJR‑Q1; SCIE WOS: 8, Scopus: 9 2014
Intravenous immunoglobulin promotes antitumor responses by modulating macrophage polarization Journal of Immunology 0022-1767 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 35 2014
Leptin signaling in skeletal muscle after bed rest in healthy humans European Journal of Applied Physiology 1439-6319 JCR‑Q2; SJR‑Q1; SCIE WOS: 20, Scopus: 20 2014
Lipid profiling and transcriptomic analysis reveals a functional interplay between estradiol and growth hormone in liver PLoS ONE 1932-6203 JCR‑Q1; SJR‑Q1; SCIE WOS: 9, Scopus: 9 2014
Microsatellite instability and ploidy status define three categories with distinctive prognostic impact in endometrioid endometrial cancer Oncotarget 1949-2553 JCR‑Q1; SJR‑Q1 WOS: 12, Scopus: 13 2014
Other TLR Pathway Defects Stiehm''s Immune Deficiencies WOS: 0, Scopus: 3 2014
Radio-induced apoptosis of peripheral blood CD8 T lymphocytes is a novel prognostic factor for survival in cervical carcinoma patients Strahlentherapie und Onkologie 0179-7158 JCR‑Q1; SJR‑Q1; SCIE WOS: 14, Scopus: 15 2014
Seguimiento de 3 años de pacientes con lesiones de bifurcación tratados con stents liberadores de sirolimus o everolimus: estudio de colaboración de SEAside y CORpal Revista Espanola de Cardiologia 0300-8932 JCR‑Q2; SJR‑Q2; FECYT; SCIE WOS: 13, Scopus: 16 2014
Simvastatin impairs growth hormone-activated signal transducer and activator of transcription (STAT) signaling pathway in UMR-106 osteosarcoma cells PLoS ONE 1932-6203 JCR‑Q1; SJR‑Q1; SCIE WOS: 17, Scopus: 21 2014
Título Revista/Libro ISSN/ISBN Impacto Citas Año
Single nucleotide polymorphisms in DNA repair genes as risk factors associated to prostate cancer progression BMC Medical Genetics 1471-2350 JCR‑Q3; SJR‑Q2; SCIE WOS: 15, Scopus: 17 2014
SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer Carcinogenesis 0143-3334 JCR‑Q1; SJR‑Q1; SCIE WOS: 32, Scopus: 35 2014
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Surfactant protein A genetic variants associate with severe respiratory insufficiency in pandemic influenza A virus infection Critical Care 1466-609X JCR‑Q1; SCIE WOS: 45, Scopus: 46 2014
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Variable functional recovery and minor cell loss in the ganglion cell layer of the lizard gallotia galloti after optic nerve axotomy Experimental Eye Research 0014-4835 JCR‑Q1; SJR‑Q1; SCIE WOS: 4, Scopus: 4 2014
Autologous platelet-poor plasma decreases the bronchial stump necrosis in rat Journal of Surgical Research 0022-4804 JCR‑Q2; SJR‑Q1; SCIE WOS: 1, Scopus: 1 2013
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Characterisation of PIMT KO mice: a model of deficient protein repair Diabetologia (Berlin) 0012-186X JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2013
Common genomic signaling among initial DNA damage and radiation-induced apoptosis in peripheral blood lymphocytes from locally advanced breast cancer patients Breast 0960-9776 JCR‑Q1; SJR‑Q1; SCIE WOS: 6, Scopus: 7 2013
Control of cholesterol metabolism and plasma high-density lipoprotein levels by microRNA-144 Circulation research 0009-7330 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 180 2013
Critical role for free radicals on sprint exercise-induced CaMKII and AMPK¿ phosphorylation in human skeletal muscle Journal of Applied Physiology 8750-7587 JCR‑Q1; SJR‑Q2; SCIE WOS: 39, Scopus: 46 2013
Estrogens regulate the hepatic effects of growth hormone, a hormonal interplay with multiple fates Frontiers in Endocrinology 1664-2392 SCIE WOS: 0, Scopus: 32 2013
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Isoinertial and isokinetic sprints: Muscle signalling International Journal of Sports Medicine 0172-4622 JCR‑Q1; SJR‑Q1; SCIE WOS: 5, Scopus: 5 2013
Late bone metastasis from an apparently benign oncocytic follicular thyroid tumor Endocrinology, Diabetes and Metabolism Case Reports 2052-0573 WOS: 0, Scopus: 0 2013
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Super-oxidized solution (dermacyn wound care) as adjuvant treatment in the postoperative management of complicated diabetic foot osteomyelitis: Preliminary experience in a specialized department International Journal of Lower Extremity Wounds 1534-7346 JCR‑Q3; SJR‑Q2; SCIE WOS: 17, Scopus: 16 2013
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The nuclear receptor LXR¿ controls the functional specialization of splenic macrophages Nature Immunology 1529-2908 SJR‑Q1; SCIE WOS: 121, Scopus: 129 2013
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The role of mannose-binding lectin in pneumococcal infection European Respiratory Journal 0903-1936 JCR‑Q1; SJR‑Q1; SCIE WOS: 30, Scopus: 36 2013
The suppressor of cytokine signalling-2 regulates the effects of estradiol on body growth FEBS Journal 1742-464X JCR‑Q2; SCIE WOS: 0, Scopus: 0 2013
Transient Exposition to Neonatal Hypothyroidism Increases Hepatic Gene Expression of Suppressors of Cytokine Signaling (SOCS) During Catch-Up Growth and in Adulthood Proceedings Of The 6Th European Congress Of Pharmacology WOS: 0, Scopus: 0 2013
Unique SERM-like properties of the novel fluorescent tamoxifen derivative FLTX1 European Journal of Pharmaceutics and Biopharmaceutics 0939-6411 JCR‑Q1; SJR‑Q1; SCIE WOS: 16, Scopus: 16 2013
XRhythmic modulation of the hematopoietic niche through neutrophil clearance Cell 0092-8674 JCR‑Q1; SJR‑Q1; SCIE WOS: 386, Scopus: 485 2013
Androgen receptor gene polymorphisms and the fat-bone axis in young men and women Journal of Andrology 0196-3635 JCR‑Q2 WOS: 10, Scopus: 12 2012
Anti-Inflammatory Activity of a Novel Family of Aryl Ureas Compounds in an Endotoxin-Induced Airway Epithelial Cell Injury Model PLoS ONE 1932-6203 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 26 2012
Coordinate regulation of neutrophil homeostasis by liver X receptors in mice Journal of Clinical Investigation 0021-9738 SJR‑Q1; SCIE WOS: 97, Scopus: 113 2012
Enhanced As160 Phosphorylation In Response To Sprint Exercise In Severe Acute Hypoxia Medicine and Science in Sports and Exercise 0195-9131 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2012
Fc¿ Receptor Deficiency Attenuates Diabetic Nephropathy Journal of the American Society of Nephrology : JASN 1046-6673 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2012
GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance Diabetes (New York, N.Y.) 0012-1797 JCR‑Q1; SJR‑Q1; SCIE WOS: 77, Scopus: 83 2012
IgM+IgD+CD27+ B cells are markedly reduced in IRAK-4¿, MyD88-, and TIRAP- but not UNC-93B¿deficient patients Blood 0006-4971 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 76 2012
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Influence of neonatal hypothyroidism on hepatic gene expression and lipid metabolism in adulthood PLoS ONE 1932-6203 JCR‑Q1; SJR‑Q1; SCIE WOS: 14, Scopus: 18 2012
Microsatellite polymorphism in the EGFR, NOTCH4 and E2F4 genes and their association with breast cancer risk International Journal of Biological Markers 0393-6155 JCR‑Q3; SJR‑Q2; SCIE WOS: 2, Scopus: 2 2012
Neuronal and glial differentiation during lizard (Gallotia galloti) visual system ontogeny Journal of Comparative Neurology 0021-9967 JCR‑Q1; SJR‑Q1; SCIE WOS: 14, Scopus: 13 2012
Nitric oxide, vascular function and exercise Biochemist 0954-982X WOS: 0, Scopus: 0 2012
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Oxysterol-induced soluble endoglin release and its involvement in hypertension Circulation (New York, N.Y.) 0009-7322 JCR‑Q1; SJR‑Q1; SCIE WOS: 76, Scopus: 80 2012
Prediction of normal tissue toxicity as part of the individualized treatment with radiotherapy in oncology patients Surgical Oncology 0960-7404 JCR‑Q2; SJR‑Q1; SCIE WOS: 25, Scopus: 28 2012
Randomized study comparing everolimus- and sirolimus-eluting stents in patients with bifurcation lesions treated by provisional side-branch stenting Catheterization and Cardiovascular Interventions 1522-1946 JCR‑Q2; SJR‑Q2; SCIE WOS: 23, Scopus: 25 2012
Searching for novel molecular targets of chronic rejection in an orthotopic experimental lung transplantation model Journal of Heart and Lung Transplantation 1053-2498 JCR‑Q1; SJR‑Q1; SCIE WOS: 9, Scopus: 8 2012
Skeletal muscle signaling response to sprint exercise in men and women European Journal of Applied Physiology 1439-6319 JCR‑Q1; SJR‑Q1; SCIE WOS: 27, Scopus: 27 2012
SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice FASEB Journal 0892-6638 JCR‑Q1; SJR‑Q1; SCIE WOS: 56, Scopus: 57 2012
The Influence of Estrogens on the Biological and TherapeuticActions of Growth Hormone in the Liver Pharmaceuticals 1424-8247 SJR‑Q2; ESCI WOS: 1, Scopus: 5 2012
Traducción y validación de la versión española de la Échelle des Perceptions du Soutien à l¿Autonomie en Sport Universitas Psychologica 1657-9267 JCR‑Q3; SJR‑Q3; SSCI WOS: 3, Scopus: 1 2012
Variants at the promoter of the interleukin-6 gene are associated with severity and outcome of pneumococcal community-acquired pneumonia Intensive Care Medicine 0342-4642 JCR‑Q1; SJR‑Q1; SCIE WOS: 46, Scopus: 47 2012
Androgen receptor gene polymorphisms lean mass and performance in young men British Journal of Sports Medicine 0306-3674 JCR‑Q1; SJR‑Q1; SCIE WOS: 15, Scopus: 18 2011
Combined low initial DNA damage and high radiation-induced apoptosis confers clinical resistance to long-term toxicity in breast cancer patients treated with high-dose radiotherapy Radiation Oncology 1748-717X JCR‑Q2; SJR‑Q1; SCIE WOS: 29, Scopus: 31 2011
Cooperation of adenosine with macrophage toll-4 receptor agonists leads to increased glycolytic flux through the enhanced expression of PFKFB3 gene Journal of Biological Chemistry 0021-9258 JCR‑Q1; SJR‑Q1; SCIE WOS: 54, Scopus: 64 2011
Development of astroglia heterogeneously expressing Pax2, vimentin and GFAP during the ontogeny of the optic pathway of the lizard (Gallotia galloti): An immunohistochemical and ultrastructural study Cell and Tissue Research 0302-766X JCR‑Q3; SJR‑Q1; SCIE WOS: 12, Scopus: 12 2011
Estrogens in the Control of Growth Hormone Actions in Liver WOS: 1, Scopus: 0 2011
Expression of BDNF and NT-3 during the ontogeny and regeneration of the lacertidian (Gallotia galloti) visual system Developmental Neurobiology 1932-8451 JCR‑Q2; SJR‑Q2; SCIE WOS: 10, Scopus: 10 2011
Features of the lizard (Gallotia galloti) Conus Papillaris during the ontogeny and after optic nerve transection GLIA 0894-1491 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2011
Influence of genetic variability at the surfactant proteins A and D in community-acquired pneumonia: a prospective, observational, genetic study Critical Care 1466-609X JCR‑Q1; SCIE WOS: 32, Scopus: 37 2011
Involvement of adenosine A<inf>2A</inf>receptors in engulfment-dependent apoptotic cell suppression of inflammation Journal of Immunology 0022-1767 JCR‑Q1; SJR‑Q1; SCIE WOS: 56, Scopus: 59 2011
Is sprint exercise a leptin signaling mimetic in human skeletal muscle? Journal of Applied Physiology 8750-7587 JCR‑Q1; SJR‑Q2; SCIE WOS: 22, Scopus: 27 2011
Liver X receptor agonist downregulates growth hormone signaling in the liver Hormone Molecular Biology and Clinical Investigation 1868-1883 ESCI WOS: 3, Scopus: 3 2011
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Liver X receptors as regulators of macrophage inflammatory and metabolic pathways Biochimica et Biophysica Acta - Molecular Basis of Disease 0925-4439 JCR‑Q1; SJR‑Q1; SCIE WOS: 82, Scopus: 100 2011
Morphofunctional Specialization Of Astrocytes In The Optic Nerve And Tract Of The Lizard Gallotia Galloti GLIA 0894-1491 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2011
Normal mitochondrial function and increased fat oxidation capacity in leg and arm muscles in obese humans International Journal of Obesity 0307-0565 JCR‑Q1; SJR‑Q1; SCIE WOS: 68, Scopus: 76 2011
Ontogeny of the conus papillaris of the lizard Gallotia galloti and cellular response following transection of the optic nerve: An immunohistochemical and ultrastructural study Cell and Tissue Research 0302-766X JCR‑Q3; SJR‑Q1; SCIE WOS: 3, Scopus: 3 2011
Partial recessive IFN-gamma R1 deficiency: genetic, immunological and clinical features of 14 patients from 11 kindreds Human Molecular Genetics 0964-6906 JCR‑Q1; SJR‑Q1; SCIE WOS: 71, Scopus: 84 2011
Pulsed ultrasounds accelerate healing of rib fractures in an experimental animal model: An effective new thoracic therapy? Journal of Thoracic and Cardiovascular Surgery 0022-5223 JCR‑Q1; SJR‑Q1; SCIE WOS: 5, Scopus: 3 2011
Recovery Of Pupillary Light Reflex But Not Of Behavioural Responses Occurs After Complete Optic Nerve Transection In The Lizard Gallotia Galloti GLIA 0894-1491 JCR‑Q1; SJR‑Q1; SCIE WOS: 1, Scopus: 0 2011
Repeated muscle biopsies through a single skin incision do not elicit muscle signaling, but IL-6 mRNA and STAT3 phosphorylation increase in injured muscle Journal of Applied Physiology 8750-7587 JCR‑Q1; SJR‑Q2; SCIE WOS: 35, Scopus: 37 2011
Role of Liver X Receptors In the Regulation of Effector Functions of Fibroblast-Like Synoviocytes In Rheumatoid Arthritis Arthritis and rheumatism 0004-3591 JCR‑Q1 WOS: 0, Scopus: 0 2011
Role of mannose-binding lectin polymorphisms in the susceptibility to and severity of pneumococcal community-acquired pneumonia Intensive Care Medicine 0342-4642 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 0 2011
Simvastatin induces early apoptosis and decreases cell viability in osteosarcoma and trophoblast cells, causing cell type-selective effects International Journal of Molecular Medicine 1107-3756 JCR‑Q3; SJR‑Q3; SCIE WOS: 0, Scopus: 0 2011
Successful management of chronic multifocal Q fever osteomyelitis with adjuvant interferon-gamma therapy Pediatric Infectious Disease Journal 0891-3668 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 17 2011
Sun exposure induces rapid immunological changes in skin and peripheral blood in patients with psoriasis British journal of dermatology (1951. Print) 0007-0963 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 52 2011
Sun exposure rapidly reduces plasmacytoid dendritic cells and inflammatory dermal dendritic cells in psoriatic skin British journal of dermatology (1951. Print) 0007-0963 JCR‑Q1; SJR‑Q1; SCIE WOS: 0, Scopus: 22 2011
The Fc¿ receptor IIA-H/H131 genotype is associated with bacteremia in pneumococcal community-acquired pneumonia Critical Care Medicine 0090-3493 JCR‑Q1; SJR‑Q1; SCIE WOS: 39, Scopus: 43 2011
Training, leptin receptors and SOCS3 in human muscle International Journal of Sports Medicine 0172-4622 JCR‑Q1; SJR‑Q1; SCIE WOS: 7, Scopus: 7 2011
Amifostine modulates radio-induced apoptosis of peripheral blood lymphocytes in head and neck cancer patients Journal of Radiation Research 0449-3060 JCR‑Q2; SCIE WOS: 7, Scopus: 9 2010
AMPK Phosporylation, Sirt1 And PGC-1a Protein Expression After Sprint Exercise in Fed and Fasted Conditions Medicine and Science in Sports and Exercise 0195-9131 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2010
Bed Rest-Induced Changes in TBC1D4 Phosphorylation and Glycogen Synthase Activity. Effects of Acute Exercise Diabetes (New York, N.Y.) 0012-1797 JCR‑Q1; SCIE WOS: 1, Scopus: 0 2010
Bone mass and the CAG and GGN androgen receptor polymorphisms in young men PLoS ONE 1932-6203 JCR‑Q1; SCIE WOS: 17, Scopus: 20 2010
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Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency Medicine 0025-7974 JCR‑Q1; SCIE WOS: 0, Scopus: 327 2010
Clinical significance of the isolation of Staphylococcus epidermidis from bone biopsy in diabetic foot osteomyelitis Diabetic Foot and Ankle 2000-625X ESCI WOS: 0, Scopus: 17 2010
Cytotoxic triterpenoids from Maytenus retusa Journal of Natural Products 0163-3864 JCR‑Q1; SCIE WOS: 26, Scopus: 27 2010
Distribution of TYMS, MTHFR, p53 and MDR1 gene polymorphisms in patients with breast cancer treated with neoadjuvant chemotherapy Cancer Epidemiology 1877-7821 JCR‑Q4; SCIE WOS: 27, Scopus: 28 2010
Expression of neuronal markers, synaptic proteins, and glutamine synthetase in the control and regenerating lizard visual system Journal of Comparative Neurology 0021-9967 JCR‑Q1; SCIE WOS: 17, Scopus: 17 2010
Ezrin mediates c-Myc actions in prostate cancer cell invasion Oncogene 0950-9232 JCR‑Q1; SCIE WOS: 50, Scopus: 55 2010
Factors involved in the progress of preclinical atherosclerosis associated with systemic lupus erythematosus: A 2-year longitudinal study Annals of the rheumatic diseases 0003-4967 JCR‑Q1; SCIE WOS: 44, Scopus: 52 2010
Genetic variability in the severity and outcome of community-acquired pneumonia Respiratory Medicine 0954-6111 JCR‑Q2; SCIE WOS: 0, Scopus: 49 2010
Influence of Hypoxia and Oxidative Stress on Plasma Leptin Responses to Sprint Exercise in Humans Medicine and Science in Sports and Exercise 0195-9131 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2010
In-hospital complications and mortality following major lower extremity amputations in a series of predominantly diabetic patients International Journal of Lower Extremity Wounds 1534-7346 SCIE WOS: 19, Scopus: 21 2010
Intracellular signaling pathways activated by leptin and its modulation by exercise (I) Archivos de Medicina del Deporte 0212-8799 FECYT WOS: 0, Scopus: 0 2010
Is Oxidative Stress Involved In Fatigue During High Intensity Sprint Exercise In Severe Acute Hypoxia? Medicine and Science in Sports and Exercise 0195-9131 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2010
Leptin receptor 170 kDa (OB-R170) protein expression is reduced in obese human skeletal muscle: a potential mechanism of leptin resistance Experimental Physiology 0958-0670 JCR‑Q2; SCIE WOS: 41, Scopus: 47 2010
Muscle hypertrophy and increased expression of leptin receptors in the musculus triceps brachii of the dominant arm in professional tennis players European Journal of Applied Physiology 1439-6319 JCR‑Q2; SCIE WOS: 25, Scopus: 28 2010
Oesophageal squamous cell carcinoma in a young adult with IL-12Rß1 deficiency Journal of Medical Genetics 0022-2593 JCR‑Q1; SCIE WOS: 0, Scopus: 25 2010
Papel de los receptores LXR como reguladores de la respuesta inmunitaria y la migración de las células dendríticas Vector Plus 1134-5306 WOS: 0, Scopus: 0 2010
Peripheral blood lymphocytes apoptosis predict radiation-induced late toxicity in cervical cancer patientes Radiotherapy and Oncology 0167-8140 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2010
Peripheral blood lymphocytes apoptosis predict radiation-induced late toxicity in head and neck cancer patientes Radiotherapy and Oncology 0167-8140 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2010
Prediction of clinical toxicity in locally advanced head and neck cancer patients by radio-induced apoptosis in peripheral blood lymphocytes (PBLs) Radiation Oncology 1748-717X JCR‑Q2; SCIE WOS: 30, Scopus: 34 2010
Radiation induced apoptosis and initial DNA damage are inversely related in locally advanced breast cancer patients Radiation Oncology 1748-717X JCR‑Q2; SCIE WOS: 29, Scopus: 31 2010
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Revisiting human IL-12Rß1 deficiency: A survey of 141 patients from 30 countries Medicine 0025-7974 JCR‑Q1; SCIE WOS: 0, Scopus: 325 2010
Role Of Constitutive Gene Expression Profile In The Development Of Toxicity Due To High-Dose Hyperfractionated Radical Radiotherapy In Breast Cancer Patients Radiotherapy and Oncology 0167-8140 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2010
Señalización intracelular activada por leptina y su modulación por el ejercicio físico (II) Archivos de Medicina del Deporte 0212-8799 FECYT WOS: 0, Scopus: 0 2010
SIRT1, AMP-activated protein kinase phosphorylation and downstream kinases in response to a single bout of sprint exercise: Influence of glucose ingestion European Journal of Applied Physiology 1439-6319 JCR‑Q2; SCIE WOS: 66, Scopus: 69 2010
Synthesis and in vitro antiprotozoal evaluation of substituted phenalenone analogues Bioorganic and Medicinal Chemistry 0968-0896 JCR‑Q2; SCIE WOS: 26, Scopus: 28 2010
The effect of in vivo growth hormone treatment on blood gene expression in adults with growth hormone deficiency reveals potential biomarkers to monitor growth hormone therapy Clinical Endocrinology 0300-0664 JCR‑Q2; SCIE WOS: 12, Scopus: 13 2010
Translation and validation of the Spanish version of the "Échelle de Satisfaction des Besoins Psychologiques" in the sports context Spanish Journal of Psychology 1138-7416 JCR‑Q3; FECYT; SSCI; SCIE WOS: 11, Scopus: 13 2010
TYMS, MTHFR, p53 and MDR1 gene polymorphisms in breast cancer patients treated with adjuvant therapy Cancer Epidemiology 1877-7821 JCR‑Q4; SCIE WOS: 7, Scopus: 8 2010
Variation of The Immune Profile in Colostrum, Early and Mature Milk Journal of Pediatric Gastroenterology and Nutrition 0277-2116 JCR‑Q2; SCIE WOS: 0, Scopus: 0 2010
Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR Immunity 1074-7613 SCIE WOS: 457, Scopus: 521 2009
Are diabetic foot ulcers complicated by MRSA osteomyelitis associated with worse prognosis? Outcomes of a surgical series Diabetic Medicine 0742-3071 JCR‑Q2; SCIE WOS: 0, Scopus: 43 2009
Constitutive gene expression profile segregates toxicity in locally advanced breast cancer patients treated with high-dose hyperfractionated radical radiotherapy Radiation Oncology 1748-717X SCIE WOS: 20, Scopus: 27 2009
Epidemiology of diabetes-related lower extremity amputations in Gran Canaria, Canary Islands (Spain) Diabetes Research and Clinical Practice 0168-8227 JCR‑Q3; SCIE WOS: 0, Scopus: 27 2009
Exercise and bone mass in adults Sports Medicine 0112-1642 JCR‑Q1; SCIE WOS: 255, Scopus: 293 2009
Gene polymorphisms in TYMS, MTHFR, p53 and MDR1 as risk factors for breast cancer: A case-control study Oncology Reports 1021-335X JCR‑Q3; SCIE WOS: 59, Scopus: 62 2009
Immunohistochemical Characterization Of Muller Glial Cells During The Lizard Ontogeny And After Optic Nerve Transection GLIA 0894-1491 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2009
Immunohistochemical Characterization Of Peculiar Oligodendrocytes In The Lizard Retina GLIA 0894-1491 JCR‑Q1; SCIE WOS: 1, Scopus: 0 2009
Immunohistochemical Study Of The Expression Of The P75 Neurotrophin Receptor In The Control And Regeneration Optic Nerve Of The Lizard Gallotia Galloti GLIA 0894-1491 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2009
Necrotizing soft-tissue infections in the feet of patients with diabetes: Outcome of surgical treatment and factors associated with limb loss and mortality International Journal of Lower Extremity Wounds 1534-7346 SCIE WOS: 0, Scopus: 50 2009
Origin And Distribution Of Microglial Cells During The Ontogeny And Regeneration Of The Lizard Optic Nerve GLIA 0894-1491 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2009
Título Revista/Libro ISSN/ISBN Impacto Citas Año
Prediction of clinical toxicity in localized cervical carcinoma by radio-induced apoptosis study in peripheral blood lymphocytes (PBLs) Radiation Oncology 1748-717X SCIE WOS: 40, Scopus: 42 2009
Regulación hormonal de la colestasis inducida por estrógenos Vector Plus 1134-5306 WOS: 0, Scopus: 0 2009
Short alleles of both GGN and CAG repeats at the exon-1 of the androgen receptor gene are associated to increased PSA staining and a higher Gleason score in human prostatic cancer Journal of Steroid Biochemistry and Molecular Biology 0960-0760 JCR‑Q2; SCIE WOS: 20, Scopus: 21 2009
Ultrastructural And Immunohistochemical Changes Of The Lizard Conus Papillaris After Optic Nerve Transection GLIA 0894-1491 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2009
Ultrastructural Features Of The Lizard (Gallotia Galloti) Optic Nerve Regeneration GLIA 0894-1491 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2009
Activation of liver X receptors promotes neuroprotection and reduces brain inflammation in experimental stroke Circulation (New York, N.Y.) 0009-7322 SCIE WOS: 0, Scopus: 89 2008
Ampk alpha Phosphorylation In The M. Vastus Lateralis Following Sprint Exercise In Humans Medicine and Science in Sports and Exercise 0195-9131 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2008
Analysis of growth hormone effects on hepatic gene expression in hypophysectomized rats Genomics In Endocrinology WOS: 0, Scopus: 0 2008
Androgen Receptor Gene cag and ggn Length Polymorphisms Are Associated With Lean Mass in Women Medicine and Science in Sports and Exercise 0195-9131 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2008
Arginase I induction by modified lipoproteins in macrophages: A peroxisome proliferator-activated receptor-¿/¿-mediated effect that links lipid metabolism and immunity Molecular Endocrinology 0888-8809 JCR‑Q1 WOS: 107, Scopus: 118 2008
Distribution of neurotrophin-3 during the ontogeny and regeneration of the lizard (Gallotia galloti) visual system Developmental Neurobiology 1932-8451 JCR‑Q3; SCIE WOS: 12, Scopus: 11 2008
Effects of combined strength and endurance training on the expression of leptin receptors in human skeletal muscle FASEB Journal 0892-6638 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2008
Electrocardiographic changes in rats undergoing thoracic surgery under combined parenteral anesthesia Lab Animal 0093-7355 JCR‑Q3; SCIE WOS: 1, Scopus: 4 2008
Gender dimorphism in skeletal muscle leptin receptors, serum leptin and insulin sensitivity PLoS ONE 1932-6203 SCIE WOS: 48, Scopus: 50 2008
Gender dymorphism in muscle leptin receptors FASEB Journal 0892-6638 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2008
Growth Hormone, Thyroid Hormones and Estradiol Interplay In Vivo to Regulate Gene Expression of Suppressor of Cytokine Signalling (SOCS) WOS: 1, Scopus: 0 2008
Immunomodulatory effects of the intake of fermented milk with Lactobacillus casei DN114001 in lactating mothers and their children British Journal of Nutrition 0007-1145 JCR‑Q2; SCIE WOS: 42, Scopus: 53 2008
Interleukin-10 promoter polymorphisms in patients with systemic lupus erythematosus from the Canary Islands International Journal of Immunogenetics 1744-3121 JCR‑Q4; SCIE WOS: 30, Scopus: 30 2008
LXR receptors mediate endogenous neuroprotection in acute experimental stroke Stroke 0039-2499 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2008
Mannose-binding lectin and mannose-binding lectin-associated serine protease 2 in susceptibility, severity, and outcome of pneumonia in adults Journal of Allergy and Clinical Immunology 0091-6749 JCR‑Q1; SCIE WOS: 0, Scopus: 116 2008
Título Revista/Libro ISSN/ISBN Impacto Citas Año
Modulation of AMPK signaling by sprint exercise in human skeletal muscle RED. Revista de entrenamiento deportivo 1133-0619 WOS: 0, Scopus: 0 2008
Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells Journal of Experimental Medicine 0022-1007 SCIE WOS: 0, Scopus: 378 2008
Outcomes of surgical treatment of diabetic foot osteomyelitis: A series of 185 patients with histopathological confirmation of bone involvement Diabetologia (Berlin) 0012-186X JCR‑Q1; SCIE WOS: 0, Scopus: 159 2008
Pyogenic bacterial infections in humans with MyD88 deficiency Science 0036-8075 SCIE WOS: 0, Scopus: 643 2008
Regulation of expression of Suppressors of Cytokine Signalling (SOCS) genes in hypothyroid male rats by Growth hormone, Thyroid Hormones and Estradiol FASEB Journal 0892-6638 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2008
Steroid binding sites in liver membranes: Interplay between glucocorticoids, sex steroids, and pituitary hormones Journal of Steroid Biochemistry and Molecular Biology 0960-0760 JCR‑Q2; SCIE WOS: 4, Scopus: 5 2008
Tenascin-R and axon growth-promoting molecules are up-regulated in the regenerating visual pathway of the lizard (Gallotia galloti) Developmental Neurobiology 1932-8451 JCR‑Q3; SCIE WOS: 20, Scopus: 21 2008
A comparative immunohistochemical study on BDNF distribution in the ontogeny and regeneration of the lizard (Gallotia galloti) visual system Neuron Glia Biology 1740-925X WOS: 0, Scopus: 0 2007
Arterial hypertension linked to ¿ -1-antitrypsin deficit from an etiological point of view Hipertension 0212-8241 WOS: 0, Scopus: 0 2007
Chlamydia pneumoniae-induced macrophage foam cell formation is mediated by toll-like receptor 2 Infection and Immunity 0019-9567 JCR‑Q1; SCIE WOS: 0, Scopus: 132 2007
Determination of fat tissue infiltration in human skeletal muscle biopsies FASEB Journal 0892-6638 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2007
Expression of Nogo-A and Nogo-66 receptor during development and optic nerve regeneration in the lizard, Gallotia galloti Neuron Glia Biology 1740-925X WOS: 0, Scopus: 0 2007
Hex and Prx1 up-regulation in an experimental model of focal and segmental glomerulosclerosis Nephrology Dialysis Transplantation 0931-0509 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2007
Hormonal and nutritional regulation of alternative CD36 transcripts in rat liver - A role for growth hormone in alternative exon usage BMC Molecular Biology 1471-2199 JCR‑Q2; SCIE WOS: 37, Scopus: 37 2007
Identification of the astoglial lineage in the optic nerve of lizard Gallotia galloti Neuron Glia Biology 1740-925X WOS: 0, Scopus: 0 2007
IGF-II regulates metastatic properties of choriocarcinoma cells through the activation of the insulin receptor Molecular Human Reproduction 1360-9947 JCR‑Q2; SCIE WOS: 0, Scopus: 35 2007
Immunohistochemical and ultrastructural study of the conus papillaris in the lizard (G. galloti) eye Neuron Glia Biology 1740-925X WOS: 0, Scopus: 0 2007
Immunohistochemical characterization of oligodendrocyte precursors in the visual pathway of the lizard Gallotia galloti Neuron Glia Biology 1740-925X WOS: 0, Scopus: 0 2007
In vivo transcript profiling and phylogenetic analysis identifies suppressor of cytokine signaling 2 as a direct signal transducer and activator of transcription 5b target in liver Molecular Endocrinology 0888-8809 JCR‑Q1 WOS: 58, Scopus: 63 2007
Leptin receptors in human skeletal muscle Journal of Applied Physiology 8750-7587 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2007
Título Revista/Libro ISSN/ISBN Impacto Citas Año
Leptin receptors in human skeletal muscle Journal of Applied Physiology 8750-7587 JCR‑Q1; SCIE WOS: 72, Scopus: 75 2007
N-acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRß Journal of Medicinal Chemistry 0022-2623 JCR‑Q1; SCIE WOS: 0, Scopus: 55 2007
Papel de la células satélite en la hipertrofia y regeneración muscular en respuesta al ejercicio Archivos de Medicina del Deporte 0212-8799 FECYT WOS: 0, Scopus: 0 2007
Regrowth of transected RGC axons occur despite the persistence of the glial scar in the lizard Gallotia galloti Neuron Glia Biology 1740-925X WOS: 0, Scopus: 0 2007
Regulation of the expression of prostate apoptosis response protein 4 (Par-4) in rat granulosa cells Apoptosis : an international journal on programmed cell death 1360-8185 JCR‑Q2; SCIE WOS: 6, Scopus: 7 2007
Retazos WOS: 0, Scopus: 0 2007
Role of pituitary hormones on 17¿-ethinylestradiol-induced cholestasis in rat Journal of Pharmacology and Experimental Therapeutics 0022-3565 JCR‑Q1; SCIE WOS: 27, Scopus: 30 2007
Role of satellite cells on muscle hypertrophy and muscle in response to exercise Archivos de Medicina del Deporte 0212-8799 FECYT WOS: 0, Scopus: 0 2007
Selective activation of liver X receptors by acanthoic acid-related diterpenes Molecular Pharmacology 0026-895X JCR‑Q1; SCIE WOS: 31, Scopus: 35 2007
Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity Journal of Experimental Medicine 0022-1007 SCIE WOS: 0, Scopus: 346 2007
A fast procedure for the detection of defects in toll-like receptor signaling Pediatrics 0031-4005 JCR‑Q1; SCIE WOS: 0, Scopus: 54 2006
A role for IRF3-dependent RXR¿ repression in hepatotoxicity associated with viral infections Journal of Experimental Medicine 0022-1007 SCIE WOS: 0, Scopus: 34 2006
Autosomal recessive Interleukin-1 receptor-associated kinase 4 deficiency in fourth-degree relatives Journal of Pediatrics 0022-3476 JCR‑Q1; SCIE WOS: 0, Scopus: 45 2006
Chemical composition and biological activities of the essential oils of Salvia canariensis Flavour and Fragrance Journal 0882-5734 JCR‑Q2; SCIE WOS: 9, Scopus: 13 2006
Congenital hypothyroidism causes altered lipogenic response to thyroid hormones in adult rat liver FEBS Journal 1742-464X JCR‑Q2; SCIE WOS: 0, Scopus: 0 2006
Effects of AT1 blocker and statin on early stages of renal fibrosis in an experimental model of focal and segmental glomerular sclerosis Nephrology Dialysis Transplantation 0931-0509 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2006
Influence of mannose-binding lectin on HIV infection and tuberculosis in a Western-European population Molecular Immunology 0161-5890 JCR‑Q1; SCIE WOS: 0, Scopus: 49 2006
La inestabilidad microsatélite y la hipermetilación del promotor MLH1 se asocian con la aparición tardía del cáncer de endometrio Vector Plus 1134-5306 WOS: 0, Scopus: 0 2006
La inestabilidad microsatélite y la hipermetilación del promotor mlh1 se asocian con la aparición tardía del cáncer de endometrio Vector Plus 1134-5306 WOS: 0, Scopus: 0 2006
Low clinical penetrance of mannose-binding lectin-associated serine protease 2 deficiency Journal of Allergy and Clinical Immunology 0091-6749 JCR‑Q1; SCIE WOS: 0, Scopus: 32 2006
Título Revista/Libro ISSN/ISBN Impacto Citas Año
Molecular mechanisms of estrogen action in target tissues Selective Estrogen Receptor Modulators: A New Brand of Multitarget Drugs WOS: 0, Scopus: 0 2006
Peculiar and typical oligodendrocytes are involved in an uneven myelination pattern during the ontogeny of the lizard visual pathway Journal of Neurobiology 0022-3034 JCR‑Q1 WOS: 13, Scopus: 13 2006
Perfil farmacológico del omalizumab Archivos de Bronconeumologia 0300-2896 JCR‑Q3; SCIE WOS: 0, Scopus: 2 2006
Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77 Molecular Endocrinology 0888-8809 JCR‑Q1 WOS: 0, Scopus: 169 2006
Studies of the interaction between bis(dithiocarbamato)copper(II) complexes with nitric oxide in aqueous solution and biological applications Polyhedron 0277-5387 JCR‑Q2; SCIE WOS: 23, Scopus: 26 2006
Suppressor of cytokine signaling (SOCS) 2, a protein with multiple functions Cytokine and Growth Factor Reviews 1359-6101 SCIE WOS: 148, Scopus: 154 2006
The arginase II gene is an anti-inflammatory target of liver X receptor in macrophages Journal of Biological Chemistry 0021-9258 JCR‑Q1; SCIE WOS: 75, Scopus: 79 2006
A role for the apoptosis inhibitory factor AIM/Sp¿/Api6 in atherosclerosis development Cell Metabolism 1550-4131 SCIE WOS: 0, Scopus: 243 2005
Estrogen activates classical and alternative mechanisms to orchestrate neuroprotection Current Neurovascular Research 1567-2026 JCR‑Q3; SCIE WOS: 57, Scopus: 69 2005
Exploring hepatic hormone actions using a compilation of gene expression profiles BMC Physiology 1472-6793 WOS: 0, Scopus: 37 2005
Fotopletismografía por transmisión con múltiples diodos láser en el infrarrojo cercano durante el ejercicio físico Optica Pura y Aplicada 0030-3917 ESCI WOS: 0, Scopus: 0 2005
Functional exploration of liver genome by using cDNA microarrays in a model of estrogen-induced cholestasis FEBS Journal 1742-464X SCIE WOS: 0, Scopus: 0 2005
Herpesvirus saimiri-transformed CD8<sup>+</sup>T cells as a tool to study Chediak-Higashi syndrome cytolytic lymphocytes Journal of Leukocyte Biology 0741-5400 JCR‑Q1; SCIE WOS: 0, Scopus: 7 2005
Human TLR-7-, -8-, and -9-mediated induction of IFN-¿/ß and -¿ Is IRAK-4 dependent and redundant for protective immunity to viruses Immunity 1074-7613 SCIE WOS: 0, Scopus: 237 2005
Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli Journal of Biological Chemistry 0021-9258 JCR‑Q1; SCIE WOS: 0, Scopus: 225 2005
Influence of vaccination on the nitric oxide response of gilthead seabream following infection with Photobacterium damselae subsp. piscicida Fish and Shellfish Immunology 1050-4648 JCR‑Q1; SCIE WOS: 12, Scopus: 14 2005
A Poorly Differentiated Thyroid Carcinoma with Neuroendocrine Traits Thyroid 1050-7256 JCR‑Q2; SCIE WOS: 0, Scopus: 2 2004
Aplicación de análisis multivariado para la diferenciación de individuossanos según su contenido sérico de minerales Nutrición Hospitalaria 0212-1611 SCIE WOS: 0, Scopus: 1 2004
Downregulation of the growth hormone-induced Janus kinase 2/signal transducer and activator of transcription 5 signaling pathway requires an intact actin cytoskeleton Experimental cell research 0014-4827 JCR‑Q1; SCIE WOS: 18, Scopus: 19 2004
Folate status of adults living in the Canary Islands (Spain) International Journal for Vitamin and Nutrition Research 0300-9831 JCR‑Q3; SCIE WOS: 7, Scopus: 8 2004
Título Revista/Libro ISSN/ISBN Impacto Citas Año
Intestinal candidiasis in a loggerhead sea turtle (Caretta caretta): An immunohistochemical study Veterinary Journal 1090-0233 JCR‑Q1; SCIE WOS: 14, Scopus: 18 2004
LXR-dependent gene expression is important for macrophage survival and the innate immune response Cell 0092-8674 SCIE WOS: 0, Scopus: 459 2004
Metastatic squamous cell carcinoma in two loggerhead sea turtles Caretta caretta Diseases of Aquatic Organisms 0177-5103 JCR‑Q1; SCIE WOS: 22, Scopus: 29 2004
Method for large scale isolation, culture and cryopreservation of human monocytes suitable for chemotaxis, cellular adhesion assays, macrophage and dendritic cell differentiation Journal of Immunological Methods 0022-1759 JCR‑Q2; SCIE WOS: 0, Scopus: 100 2004
Nuclear receptors in macrophage biology: At the crossroads of lipid metabolism and inflammation Annual Review of Cell and Developmental Biology 1081-0706 SCIE WOS: 0, Scopus: 253 2004
Plasma membrane oestrogen receptor mediates neuroprotection against ß-amyloid toxicity through activation of Raf-1/MEK/ERK cascade in septal-derived cholinergic SN56 cells Journal of Neurochemistry 0022-3042 JCR‑Q1; SCIE WOS: 72, Scopus: 77 2004
PPARs in atherosclerosis: The clot thickens Journal of Clinical Investigation 0021-9738 SCIE WOS: 0, Scopus: 36 2004
Proteína Hsp27 y otros marcadores moleculares en el cáncer de Tiroides (Hsp27, TPO, P53 Y K167 en el cáncer de Tiroides) . Canarias médica y quirúrgica 1696-6864 WOS: 0, Scopus: 0 2004
Pulmonary hyalohyphomycosis caused by Fusarium spp in a Kemp''s ridley sea turtle (Lepidochelys kempi): an immunohistochemical study New Zealand Veterinary Journal 0048-0169 JCR‑Q3; SCIE WOS: 13, Scopus: 19 2004
Radial glial cells, proliferating periventricular cells, and microglia might contribute to successful structural repair in the cerebral cortex of the lizard Gallotia galloti Experimental neurology 0014-4886 JCR‑Q2; SCIE WOS: 37, Scopus: 38 2004
The dinucleotide repeat polymorphism in the 3¿UTR of the CD154 qene has a functional role on protein expression and is associated with systemic lupus erythematosus Annals of the rheumatic diseases 0003-4967 JCR‑Q1; SCIE WOS: 30, Scopus: 31 2004
The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras Journal of Biological Chemistry 0021-9258 JCR‑Q1; SCIE WOS: 0, Scopus: 28 2004
Transcription of the Vascular Endothelial Growth Factor Gene in Macrophages Is Regulated by Liver X Receptors Journal of Biological Chemistry 0021-9258 JCR‑Q1; SCIE WOS: 0, Scopus: 55 2004
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue Proceedings of the National Academy of Sciences of the United States of America 0027-8424 SCIE WOS: 0, Scopus: 422 2003
Activation of nuclear factor-kappa B in the renal mass reduction-induced glomerulosclerosis. Effects of endothelin, synthesis inhibition and renin-angiotensin system (RAS) blockade Journal of the American Society of Nephrology : JASN 1046-6673 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2003
An ICI 182,780-Sensitive, Membrane-Related Estrogen Receptor Contributes to Estrogenic Neuroprotective Actions against Amyloid-Beta Toxicity Annals of the New York Academy of Sciences 0077-8923 JCR‑Q1; SCIE WOS: 14, Scopus: 14 2003
An oestrogen membrane receptor participates in estradiol actions for the prevention of amyloid-beta peptide(1-40)-induced toxicity in septal-derived cholinergic SN56 cells Journal of Neurochemistry 0022-3042 JCR‑Q1; SCIE WOS: 41, Scopus: 46 2003
Are the glial cells in the optic nerve of adult lizards involved in the regeneration of the visual system? GLIA 0894-1491 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2003
Crosstalk between LXR and Toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism Molecular Cell 1097-2765 SCIE WOS: 0, Scopus: 401 2003
Diabetes o eternidad Majorensis: Revista Electrónica de Ciencia y Tecnología 1697-5529 WOS: 0, Scopus: 0 2003
Título Revista/Libro ISSN/ISBN Impacto Citas Año
Different regeneration patterns in the CNS of Gallotia galloti lizard GLIA 0894-1491 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2003
Distribution pattern of tenascin-R in the visual pathway of the lizard Gallotia galloti GLIA 0894-1491 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2003
Estradiol prevents amyloid-beta peptide-induced cell death in a cholinergic cell line via modulation of a classical estrogen receptor Neuroscience 0306-4522 JCR‑Q1; SCIE WOS: 56, Scopus: 65 2003
Ewing''s sarcoma: Histopathological and immunohistochemical study Orthopedics 0147-7447 JCR‑Q4; SCIE WOS: 0, Scopus: 3 2003
HMGCoA reductase inhibition partially mediates tumor necrosis factor ¿-induced apoptosis in human U-937 and HL-60 cells Biochemical and biophysical research communications (Print) 0006-291X JCR‑Q2; SCIE WOS: 0, Scopus: 5 2003
H-Ras-specific activation of NF-¿B protects NIH 3T3 cells against stimulus-dependent apoptosis Oncogene 0950-9232 JCR‑Q1; SCIE WOS: 0, Scopus: 24 2003
Intratesticular delivery of tumor necrosis factor-alpha and ceramide directly abrogates steroidogenic acute regulatory protein expression and Leydig cell steroidogenesis in adult rats Endocrinology (Philadelphia) 0013-7227 JCR‑Q1; SCIE WOS: 47, Scopus: 56 2003
Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages Journal of Biological Chemistry 0021-9258 JCR‑Q1; SCIE WOS: 0, Scopus: 271 2003
Low penetrance, broad resistance, and favorable outcome of interleukin 12 receptor ß1 deficiency: Medical and immunological implications Journal of Experimental Medicine 0022-1007 SCIE WOS: 0, Scopus: 263 2003
Mannose binding lectin polymorphisms as a disease-modulating factor in women with systemic lupus erythematosus from Canary Islands, Spain Journal of Rheumatology 0315-162X JCR‑Q2; SCIE WOS: 24, Scopus: 28 2003
Neuronal differentiation patterns in the optic tectum of the lizard Gallotia galloti Brain research (Print) 0006-8993 JCR‑Q2; SCIE WOS: 11, Scopus: 12 2003
Photoaffinity labeling identification of thyroid hormone-regulated glucocorticoid-binding peptides in rat liver endoplasmic reticulum: An oligomeric protein with high affinity for 16ß-hydroxylated stanozolol Journal of Steroid Biochemistry and Molecular Biology 0960-0760 JCR‑Q2; SCIE WOS: 2, Scopus: 2 2003
Potentiation of protein kinase C ¿ activity by 15-deoxy-¿ <sup>12,14</sup> -prostaglandin J <inf>2</inf> induces an imbalance between mitogen-activated protein kinases and NF-¿B that promotes apoptosis in macrophages Molecular and Cellular Biology 0270-7306 JCR‑Q1; SCIE WOS: 0, Scopus: 42 2003
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors Nature Medicine 1078-8956 SCIE WOS: 0, Scopus: 1038 2003
Sarcoma de Ewing atípico Canarias médica y quirúrgica 1696-6864 WOS: 0, Scopus: 0 2003
Selective inhibitors of cyclooxygenase-2 delay the activation of nuclear factor ¿B and attenuate the expression of inflammatory genes in murine macrophages treated with lipopolysaccharide Molecular Pharmacology 0026-895X JCR‑Q1; SCIE WOS: 0, Scopus: 18 2003
Solubilization and photoaffinity labeling identification of glucocorticoid binding peptides in endoplasmic reticulum from rat liver Journal of Steroid Biochemistry and Molecular Biology 0960-0760 JCR‑Q2; SCIE WOS: 3, Scopus: 3 2003
Sweat Gland Carcinoma. Two New Patients with Axillary Lesions Medicina Cutanea Ibero-Latino-Americana 0210-5187 WOS: 0, Scopus: 0 2003
S100 immunoreactive glial cells in the forebrain and midbrain of the lizard Gallotia galloti during ontogeny Journal of Neurobiology 0022-3034 JCR‑Q2 WOS: 28, Scopus: 30 2003
The effect of methylenetetrahydrofolate reductase C677T common variant on hypertensive risk is not solely explained by increased plasma homocysteine values Clinical and Experimental Hypertension 1064-1963 JCR‑Q4; SCIE WOS: 32, Scopus: 34 2003
Título Revista/Libro ISSN/ISBN Impacto Citas Año
The glial distribution in the optic nerve head of the adult lizard Gallotia galloti GLIA 0894-1491 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2003
The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions Molecular and Cellular Biology 0270-7306 JCR‑Q1; SCIE WOS: 0, Scopus: 137 2003
Transitory and unilateral gliosis in the cerebral cortex of the lizard Gallotia galloti GLIA 0894-1491 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2003
Apolipoprotein B and AI distributions in Spanish population: Results of the Canarian Nutrition Survey. Clinical chemistry (Baltimore, Md.) 0009-9147 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2002
Apoptotic RGC death in the lizard is insignificant after optic nerve section possibly due to protection by increased levels of Bcl-2 expression GLIA 0894-1491 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2002
Concentraciones de Na, K, Ca y P en sueros de una muestra representativa de la población canaria Nutrición Hospitalaria 0212-1611 SCIE WOS: 0, Scopus: 0 2002
Evaluation of acute hepatotoxic effects exerted by environmental estrogens nonylphenol and 4-octylphenol in immature male rats Toxicology 0300-483X JCR‑Q1; SCIE WOS: 17, Scopus: 17 2002
Glial immunoreactivity in the optic nerve of the lizard Gallotia galloti during regeneration GLIA 0894-1491 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2002
Immunohistochemical localization of glutamine synthetase in the visual pathway during ontogeny of lizard Gallotia galloti GLIA 0894-1491 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2002
Induction of apoptosis by nitric oxide in macrophages is independent of apoptotic volume decrease Cell Death and Differentiation 1350-9047 JCR‑Q1; SCIE WOS: 0, Scopus: 50 2002
Interleukin-4 and interleukin-10 modulate nuclear factor ¿B activity and nitric oxide synthase-2 expression in Theiler''s virus-infected brain astrocytes Journal of Neurochemistry 0022-3042 JCR‑Q1; SCIE WOS: 0, Scopus: 33 2002
Monoclonal antibodies that recognize a specific stage of oligodendrocytes of the visual system of Gallotia galloti during ontogeny GLIA 0894-1491 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2002
Patterns of liver gene expression governed by TRß Molecular Endocrinology 0888-8809 JCR‑Q1 WOS: 139, Scopus: 145 2002
Prostate cancer and the androgen receptor gene Clinical and Translational Oncology 1699-048X SCIE WOS: 0, Scopus: 1 2002
Reactive radial glial cells are the main component of the gliosis after injury in the cerebral cortex of the lizard Gallotia galloti GLIA 0894-1491 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2002
Regeneration of retinal axons in the lizard Gallotia galloti is not linked to generation of new retinal ganglion cells Journal of Neurobiology 0022-3034 JCR‑Q1 WOS: 28, Scopus: 29 2002
Relationship between the activation of heat shock factor and the suppression of nuclear factor-¿B activity in rat hepatocyte cultures treated with cyclosporine A Biochemical pharmacology 0006-2952 JCR‑Q1; SCIE WOS: 0, Scopus: 13 2002
Serum copper and zinc concentrations in a representative sample of the Canarian population Journal of Trace Elements in Medicine and Biology 0946-672X JCR‑Q4; SCIE WOS: 37, Scopus: 57 2002
Steroid hormone progesterone induces cell proliferation and abnormal mitotic processes in rat liver Archives of Toxicology 0340-5761 SCIE WOS: 8, Scopus: 8 2002
S-100 immunoreactivity of the visual pathway in developing and adult lizards GLIA 0894-1491 JCR‑Q1; SCIE WOS: 0, Scopus: 0 2002
Título Revista/Libro ISSN/ISBN Impacto Citas Año
The increase in TNF-¿ levels is implicated in NF-¿B activation and inducible nitric oxide synthase expression in brain cortex after immobilization stress Neuropsychopharmacology 0893-133X JCR‑Q1; SCIE WOS: 0, Scopus: 209 2002
Transition to androgen-independence in prostate cancer Journal of Steroid Biochemistry and Molecular Biology 0960-0760 SCIE WOS: 78, Scopus: 85 2002
Characterization of basal nitric oxide production in living cells Biochimica et Biophysica Acta - Molecular Cell Research 0167-4889 JCR‑Q2; SCIE WOS: 23, Scopus: 21 2001
Effects of carvedilol in rats with induced chronic renal failure Nefrologia 0211-6995 JCR‑Q4; SCIE WOS: 3, Scopus: 0 2001
Endoplasmic reticulum stress prolongs GH-induced Janus kinase (JAK2)/signal transducer and activator of transcription (STAT5) signaling pathway Molecular Endocrinology 0888-8809 JCR‑Q1 WOS: 19, Scopus: 19 2001
Estrogen modulates norepinephrine-induced accumulation of adenosine cyclic monophosphate in a subpopulation of immortalized luteinizing hormone-releasing hormone secreting neurons from the mouse hypothalamus Neuroscience Letters 0304-3940 JCR‑Q2; SCIE WOS: 14, Scopus: 18 2001
Identification of a multiple steroid-binding protein system for the anabolic steroid stanozolol in rat liver Fundamental and Clinical Pharmacology 0767-3981 JCR‑Q3; SCIE WOS: 0, Scopus: 0 2001
Inducible nitric oxide synthase expression in brain cortex after acute restraint stress is regulated by nuclear factor ¿B-mediated mechanisms Journal of Neurochemistry 0022-3042 JCR‑Q1; SCIE WOS: 0, Scopus: 170 2001
Inhibition of the nuclear factor ¿B (NF-¿B) pathway by tetracyclic kaurene diterpenes in macrophages: Specific effects on NF-¿B-inducing kinase activity and on the coordinate activation of ERK and p38 MAPK Journal of Biological Chemistry 0021-9258 JCR‑Q1; SCIE WOS: 0, Scopus: 115 2001
Intracellular water motion decreases in apoptotic macrophages after caspase activation Cell Death and Differentiation 1350-9047 JCR‑Q1; SCIE WOS: 0, Scopus: 29 2001
Mannose-binding lectin polymorphisms in a Canary Islands (Spain) population Genes and Immunity 1466-4879 JCR‑Q1; SCIE WOS: 0, Scopus: 15 2001
Peroxisome proliferator-activated receptor-¿-independent inhibition of macrophage activation by the non-thiazolidinedione agonist L-796,449. Comparison with the effects of 15-deoxy-¿<sup>12,14</sup>-prostaglandin J<inf>2</inf> Journal of Biological Chemistry 0021-9258 JCR‑Q1; SCIE WOS: 0, Scopus: 45 2001
Protection by nitric oxide against liver inflammatory injury in animals carrying a nitric oxide synthase-2 transgene FASEB Journal 0892-6638 JCR‑Q1; SCIE WOS: 0, Scopus: 45 2001
Protein kinase C¿ is required for macrophage activation and defense against bacterial infection Journal of Experimental Medicine 0022-1007 SCIE WOS: 0, Scopus: 206 2001
Serum manganese concentrations in a representative sample of the Canarian population Biological Trace Element Research 0163-4984 JCR‑Q3; SCIE WOS: 17, Scopus: 20 2001
Serum selenium concentration in a representative sample of the Canarian population Science of the Total Environment 0048-9697 JCR‑Q1; SCIE WOS: 38, Scopus: 42 2001
The amount of estrogen receptor ¿ increases after heat shock in a cholinergic cell line from the basal forebrain Neuroscience 0306-4522 JCR‑Q2; SCIE WOS: 0, Scopus: 6 2001
The amount of estrogen receptor alpha increases after heat shock in a cholinergic cell line from the basal forebrain Neuroscience 0306-4522 JCR‑Q2; SCIE WOS: 5, Scopus: 0 2001
The low-affinity glucocorticoid binding protein: photoaffinity labeling identification and pharmacological characterization Fundamental and Clinical Pharmacology 0767-3981 JCR‑Q3; SCIE WOS: 0, Scopus: 0 2001
Apoptosis induction by nitric oxide: Contribution to elimination of activated cells in inflammatory processes Methods and Findings in Experimental and Clinical Pharmacology 0379-0355 JCR‑Q4 WOS: 0, Scopus: 0 2000
Título Revista/Libro ISSN/ISBN Impacto Citas Año
CD154 polymorphism in Spanish populations. Differences in the allelic distribution between Canary Islanders and Peninsulars European Journal of Immunogenetics 0960-7420 JCR‑Q3 WOS: 0, Scopus: 8 2000
Contribution of cyclopentenone prostaglandins to the resolution of inflammation through the potentiation of apoptosis in activated macrophages Journal of Immunology 0022-1767 JCR‑Q1; SCIE WOS: 0, Scopus: 115 2000
Evaluación bioquímica del estado nutricional de la población canaria (1998) Archivos latinoamericanos de nutrición 0004-0622 JCR‑Q4; SCIE WOS: 16, Scopus: 20 2000
Implication of glutamate in the expression of inducible nitric oxide synthase after oxygen and glucose deprivation in rat forebrain slices Journal of Neurochemistry 0022-3042 JCR‑Q1; SCIE WOS: 0, Scopus: 100 2000
Inhibition of I¿B kinase and i¿b phosphorylation by 15-deoxy- ¿(12,14)-prostaglandin J<inf>2</inf> in activated murine macrophages Molecular and Cellular Biology 0270-7306 JCR‑Q1; SCIE WOS: 0, Scopus: 273 2000
Inhibitory effect of IGF-I on type 2 nitric oxide synthase expression in Ins-1 cells and protection against activation-dependent apoptosis: Involvement of phosphatidylinositol 3-kinase Diabetes (New York, N.Y.) 0012-1797 JCR‑Q1; SCIE WOS: 0, Scopus: 43 2000
Isolation of (s)-(+)-naproxene from Musa acuminata. Inhibitory effect of naproxene and its 7-methoxy isomer on constitutive COX-1 and inducible COX-2 Planta Medica 0032-0943 JCR‑Q1; SCIE WOS: 10, Scopus: 11 2000
Long-term evolution of local, proximal and remote astrocyte responses after diverse nucleus basalis lesioning (an experimental Alzheimer model): GFAP immunocytochemical study Brain research (Print) 0006-8993 JCR‑Q2; SCIE WOS: 17, Scopus: 21 2000
Photoaffinity labeling identification of a specific binding protein for the anabolic steroids stanozolol and danazol: An oligomeric protein regulated by age, pituitary hormones, and ethinyl estradiol Endocrinology (Philadelphia) 0013-7227 JCR‑Q1; SCIE WOS: 14, Scopus: 20 2000
Regulation by ceramide of epidermal growth factor signal transduction and mitogenesis in cell lines overexpressing the growth factor receptor Cellular and Molecular Biology 0145-5680 JCR‑Q3; SCIE WOS: 8, Scopus: 8 2000
Evaluation of acute and chronic hepatotoxic effects exerted by anabolic- androgenic steroid stanozolol in adult male rats Archives of Toxicology 0340-5761 JCR‑Q1; SCIE WOS: 51, Scopus: 65 1999
Inhibition of NOS-2 expression in macrophages through the inactivation of NF-¿B by andalusol British journal of pharmacology 0007-1188 JCR‑Q1; SCIE WOS: 0, Scopus: 50 1999
Inhibition of prostaglandin synthesis up-regulates cyclooxygenase-2 induced by lipopolysaccharide and peroxisomal proliferators Journal of Pharmacology and Experimental Therapeutics 0022-3565 JCR‑Q1; SCIE WOS: 0, Scopus: 53 1999
Low levels of cathepsin D are associated with a poor prognosis in endometrial cancer British journal of cancer 0007-0920 JCR‑Q1; SCIE WOS: 14, Scopus: 18 1999
Negative regulation by phosphatidylinositol 3-kinase of inducible nitric oxide synthase expression in macrophages Journal of Immunology 0022-1767 JCR‑Q1; SCIE WOS: 0, Scopus: 109 1999
Negative regulation by protein tyrosine phosphatase of IFN-¿-dependent expression of inducible nitric oxide synthase Journal of Immunology 0022-1767 JCR‑Q1; SCIE WOS: 0, Scopus: 28 1999
Thyroid hormone regulation of rat hepatocyte proliferation and polyploidization American Journal of Physiology - Gastrointestinal and Liver Physiology 0193-1857 JCR‑Q1; SCIE WOS: 39, Scopus: 40 1999
Chemiluminescence-based detection of minute amounts of apoptotic DNA BioTechniques 0736-6205 JCR‑Q2; SCIE WOS: 8, Scopus: 9 1998
Cutaneous poxvirus-like infection in a captive Hermann''s tortoise (Testudo hermanni) Veterinary Record 0042-4900 JCR‑Q1; SCIE WOS: 7, Scopus: 11 1998
Solubilization and characterization of [H-3]stanozolol and [H-3]dexamethasone binding sites from male rat liver microsomes Naunyn-Schmiedeberg''s Archives of Pharmacology 0028-1298 JCR‑Q1; SCIE WOS: 0, Scopus: 0 1998
Título Revista/Libro ISSN/ISBN Impacto Citas Año
Tamoxifen aziridine binding to cytosolic proteins from human breast specimens is negatively associated with estrogen receptors, progesterone receptors, pS2, and cathepsin-D Breast Cancer Research and Treatment 0167-6806 JCR‑Q2; SCIE WOS: 2, Scopus: 2 1998
The two native estrogen receptor forms of 8S and 4S present in cytosol from human uterine tissues display opposite reactivities with the antiestrogen tamoxifen aziridine and the estrogen responsive element Journal of Steroid Biochemistry and Molecular Biology 0960-0760 JCR‑Q2; SCIE WOS: 9, Scopus: 11 1998
Effect of the protein phosphatase inhibitor okadaic acid on FSH-induced granulosa cell steroidogenesis Journal of Endocrinology 0022-0795 JCR‑Q2; SCIE WOS: 10, Scopus: 13 1997
Effects of the novel multiple-action agent carvedilol on severe nephrosclerosis in renal ablated rats Journal of Pharmacology and Experimental Therapeutics 0022-3565 JCR‑Q1; SCIE WOS: 22, Scopus: 22 1997
Estrogen antagonism on T-3 and growth hormone control of the liver microsomal low-affinity glucocorticoid binding site (LAGS) Journal of Steroid Biochemistry and Molecular Biology 0960-0760 JCR‑Q2; SCIE WOS: 6, Scopus: 6 1997
Evaluation of drug consumption in the population of Andorra Farmacia Clinica 0212-6583 WOS: 0, Scopus: 0 1997
Expression of hepatocyte nuclear factor 6 in rat liver is sex-dependent and regulated by growth hormone Proceedings of the National Academy of Sciences of the United States of America 0027-8424 JCR‑Q1; SCIE WOS: 0, Scopus: 92 1997
Induction of guanosine triphosphate-cyclohydrolase by follicle- stimulating hormone enhances interleukin-1ß-stimulated nitric oxide synthase activity in granulosa cells Endocrinology (Philadelphia) 0013-7227 JCR‑Q1; SCIE WOS: 17, Scopus: 17 1997
Quantitative analysis of p185(HER-2/neu) protein in breast cancer and its association with other prognostic factors International Journal of Cancer 0020-7136 JCR‑Q1; SCIE WOS: 16, Scopus: 15 1997
Quiste gigante intracraneal Revista cli¿nica espan¿ola (Ed. impresa) 0014-2565 JCR‑Q4; SCIE WOS: 0, Scopus: 0 1997
Retinol (vitamin A) is a cofactor in CD3-induced human T-lymphocyte activation Immunology 0019-2805 JCR‑Q1; SCIE WOS: 0, Scopus: 29 1997
Hormone dependency of breast cancer: A century since Beatson Oncologia 0378-4835 WOS: 0, Scopus: 0 1996
Identification of a specific binding site for the anabolic steroid stanozolol in male rat liver microsomes Journal of Pharmacology and Experimental Therapeutics 0022-3565 SCIE WOS: 10, Scopus: 13 1996
Interleukin-1ß stimulates sphingomyelin hydrolysis in cultured granulosa cells: Evidence for a regulatory role of ceramide on progesterone and prostaglandin biosynthesis Endocrinology (Philadelphia) 0013-7227 SCIE WOS: 62, Scopus: 64 1996
La traducción del acmeísmo en lengua española Philologica canariensia 1136-3169 ESCI WOS: 0, Scopus: 0 1996
Validation of a differential PCR and an ELISA procedure in studying HER-2/neu status in breast cancer International Journal of Cancer 0020-7136 SCIE WOS: 21, Scopus: 22 1996
Development of astroglial cells in the encephalon of Gallotia galloti: A Golgi technique study Journal of Morphology 0362-2525 SCIE WOS: 2, Scopus: 2 1995
Diseases involving the T-cell receptor/CD3 complex Critical Reviews in Oncology/Hematology 1040-8428 SCIE WOS: 0, Scopus: 3 1995
3H Dexamethasone Binding Activity in Liver Microsomes is Modulated Differently by 17 ¿¿Alkylated Androgens and Testosterone in vivo Pharmacology and Toxicology 0901-9928 WOS: 0, Scopus: 7 1995
Age-related changes in the induction of tyrosine aminotransferase by dexamethasone: correlation with the low-affinity glucocorticoid binding sites Mechanisms of Ageing and Development 0047-6374 SCIE WOS: 5, Scopus: 5 1994
Título Revista/Libro ISSN/ISBN Impacto Citas Año
Ethinylestradiol interacts with liver microsomes and induces binding sites for steroid hormones in the male rat liver Journal of Pharmacology and Experimental Therapeutics 0022-3565 SCIE WOS: 9, Scopus: 10 1994
Peripheral blood reduction of memory (CD29<sup>+</sup>, CD45RO<sup>+</sup>, and "Bright" CD2<sup>+</sup>and LFA-1<sup>+</sup>) T lymphocytes in Papillon-Lefèvre syndrome Human Immunology 0198-8859 SCIE WOS: 0, Scopus: 13 1994
Primary T lymphocyte immunodeficiency associated with a selective impairment of CD2, CD3, CD43 (but not CD28)-mediated signal transduction Clinical and experimental immunology (Print) 0009-9104 SCIE WOS: 0, Scopus: 5 1994
Renal adenocarcinoma with multicystic pattern Actas Urologicas Espanolas 0210-4806 FECYT; SCIE WOS: 0, Scopus: 0 1994
Stanozolol and danazol, unlike natural androgens, interact with the low affinity glucocorticoid-binding sites from male rat liver microsomes Endocrinology (Philadelphia) 0013-7227 SCIE WOS: 31, Scopus: 32 1994
The role of growth hormone in regulation of low affinity glucocorticoid-binding sites from male rat liver microsomes Endocrinology (Philadelphia) 0013-7227 SCIE WOS: 12, Scopus: 11 1994
Lugares de unión de baja afinidad para glucocorticoides: un modelo para el estuido de la regulación multihormonal de proteínas microsomiales hepáticas Revista de la Academia Canaria de Ciencias 1130-4723 WOS: 0, Scopus: 0 1993
Prognostic factors in thyroid differentiated carcinoma Revista cli¿nica espan¿ola (Ed. impresa) 0014-2565 SCIE WOS: 0, Scopus: 3 1993
Selective disbalances of peripheral blood T lymphocyte subsets in human CD3¿ deficiency European Journal of Immunology 0014-2980 SCIE WOS: 0, Scopus: 22 1993
T lymphocyte signalling defects and immunodeficiency due to the lack of CD3¿ Immunodeficiency 1067-795X WOS: 0, Scopus: 26 1993
Endometrial stromal sarcoma expression of estrogen receptors, progesterone receptors and estrogen-induced srp27 (24K) suggests hormone responsiveness Journal of Steroid Biochemistry and Molecular Biology 0960-0760 SCIE WOS: 36, Scopus: 45 1992
From Pathology to Physiology of the Human T¿Lymphocyte Receptor Scandinavian Journal of Immunology 0300-9475 SCIE WOS: 0, Scopus: 6 1992
Human T-cell activation deficiencies Immunology Today 0167-5699 WOS: 0, Scopus: 37 1992
Temporal muscle leiomyoma Skin Cancer 0871-2549 WOS: 0, Scopus: 0 1992
The estradiol induction of the microsomal low-affinity glucocorticoid binding sites (LAGS) in the male rat liver is independent of the endocrine status Journal of Steroid Biochemistry and Molecular Biology 0960-0760 SCIE WOS: 5, Scopus: 4 1992
Large¿volume paracentesis and intravenous saline: Effects on the renin¿angiotensin system Hepatology 0270-9139 SCIE WOS: 31, Scopus: 38 1991
Thyroid hormones and glucocorticoids act synergistically in the regulation of the low affinity glucocorticoid binding sites in the male rat liver Endocrinology (Philadelphia) 0013-7227 SCIE WOS: 17, Scopus: 17 1991
Glucocorticoid receptor stability: Preservation of dephosphorylation and sulfhydryl group oxidation Medical Science Research 0269-8951 WOS: 0, Scopus: 0 1990
Paraneoplastic eosinophilia: hypereosinophilic syndrome and disseminated carcinoma Revista cli¿nica espan¿ola (Ed. impresa) 0014-2565 SCIE WOS: 0, Scopus: 0 1990
Monoclonal antibody characterization of progesterone receptors, estrogen receptors and the stress-responsive protein of 27 kDa (SRP27) in human uterine leiomyoma Journal of Steroid Biochemistry 0022-4731 WOS: 16, Scopus: 16 1989
Título Revista/Libro ISSN/ISBN Impacto Citas Año
Severe intrahepatic cholestasis in sepsis caused by Pseudomonas fluorescens Revista cli¿nica espan¿ola (Ed. impresa) 0014-2565 SCIE WOS: 0, Scopus: 1 1989
Steroid induction of low-affinity glucocorticoid binding sites in rat liver microsomes Journal of Steroid Biochemistry 0022-4731 WOS: 20, Scopus: 15 1989
Sweet syndrome: presentation of an atypical case and review of the literature Revista cli¿nica espan¿ola (Ed. impresa) 0014-2565 SCIE WOS: 0, Scopus: 2 1989
Tamoxifen decreases the estradiol induced progesterone receptors by interfering with nuclear estrogen receptor accumulation Journal of Steroid Biochemistry 0022-4731 WOS: 13, Scopus: 13 1989
A 46-kDa antigen associated with estrogen receptor in human breast cancer Journal of Steroid Biochemistry 0022-4731 WOS: 0, Scopus: 14 1988
Median rhomboid glossitis: current problems and personal experience Avances en odontoestomatologia 0213-1285 WOS: 0, Scopus: 0 1988
Serum androgen levels after streptozotocin administration in the male rat Revista Espanola de Fisiologia 0034-9402 WOS: 3, Scopus: 4 1988
Influencia ovárica y adrenal en la ontogénesis de los receptores citosólicos y nucleares uterinos de estrógenos Revista Espanola de Fisiologia 0034-9402 WOS: 0, Scopus: 0 1987
Ovarian and adrenal influence on the ontogenesis of uterine cytosol and nuclear receptors of estrogens Revista Espanola de Fisiologia 0034-9402 WOS: 0, Scopus: 0 1987
Ovaric and adrenal influence on the ontogeny of the cytosolic and nuclear uterine estrogen-receptor Revista Espanola de Fisiologia 0034-9402 WOS: 0, Scopus: 0 1987
Relationship between unbound oestrogen receptors in the uterus and anterior pituitary gland after implantation of oestradiol-17ß into rats Journal of Endocrinology 0022-0795 SCIE WOS: 2, Scopus: 2 1987
Absence of ovarian control of uterine and pituitary estrogen receptor concentration during the first weeks of life in the rat IRCS Medical Science 0305-6651 WOS: 0, Scopus: 0 1986
Effect of perinatal androgenization on the estrogen receptor content evolution in anterior pituitary and uterus during prepubertal development of the rat IRCS Medical Science 0305-6651 WOS: 0, Scopus: 0 1986
Time course of anterior pituitary estrogen receptor after low 17ß-estradiol doses in ovariectomized rats Journal of Steroid Biochemistry 0022-4731 WOS: 3, Scopus: 2 1985
Association of medullary and papillary carcinoma of the thyroid Revista cli¿nica espan¿ola (Ed. impresa) 0014-2565 SCIE WOS: 0, Scopus: 0 1984
Relations between cytosolic and nuclear estrogen receptors in castrated rat uterus following low 17ß-estradiol doses Journal of Steroid Biochemistry 0022-4731 WOS: 13, Scopus: 9 1984
Relations between 3H-Estradiol uptake and receptor content of estrogen responsive tissues of castrated female rat Revista Espanola de Fisiologia 0034-9402 WOS: 1, Scopus: 0 1984
Relations between<sup>3</sup>H-estradiol uptake and receptor content of estrogen responsive tissues of castrated female rat Revista Espanola de Fisiologia 0034-9402 WOS: 0, Scopus: 2 1984
The nuclear estrogen receptor in the rat uterus throughout the estrous cycle and its relation to the cytosolic progesterone receptor IRCS Medical Science 0305-6651 WOS: 1, Scopus: 2 1983
Induction of estrogen receptor synthesis in pituitary and uterus by low estradiol doses IRCS Medical Science 0305-6651 WOS: 0, Scopus: 0 1982
Título Autor Director/es F.lectura
Evaluación de un nuevo híbrido naftoquinona-benzoxazepina (CM728) como agente antitumoral en cáncer de mama triple negativo SPÍNOLA LASSO, ELENA DÍAZ CHICO, JUAN CARLOS
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ESTUDIO DE FACTORES CLÍNICOS Y ANATOMOPATOLÓGICOS EN LA IMPLEMENTACIÓN DEL DIAGNÓSTICO DE CÁNCER DE ENDOMETRIO CON FENOTIPO DE INESTABILIDAD DE MICROSATÉLITES: MODELO PREDICTIVO. GONZÁLEZ VILLA, ISABEL CABRERA GALVÁN, JUAN JOSÉ
LORO FERRER, JUAN FRANCISCO 		28-07-2023
Identificación y evaluación preclínica de nuevas moléculas de pequeño tamaño con actividad antitumoral en cáncer de mama dependiente de estrógenos. GUERRA RODRÍGUEZ, MIGUEL ALFONSO GUERRA HERNÁNDEZ, CARLOS BORJA
FERNÁNDEZ PÉREZ, LEANDRO FCO
RECIO CRUZ, CARLOTA PILAR 		26-01-2023
ESTUDIO DE ALFA-1 ANTITRIPSINA EN PACIENTES ASMÁTICOS ALÉRGICOS A ÁCAROS DE POLVO DOMÉSTICO EN EL ÁREA NORTE DE GRAN CANARIA SUÁREZ LORENZO, ISADORA RODRÍGUEZ GALLEGO, JOSÉ CARLOS
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SUSCEPTIBILIDAD A LA AFECCIÓN NEUMOCÓCICA EN NIÑOS Y EN ADULTOS: DE LOS EFECTOS MENDELIANOS DE LA INMUNIDAD A LOS ESTUDIOS GENÉTICOS POBLACIONALES HERNÁNDEZ BRITO, ELISA RODRÍGUEZ GALLEGO, JOSÉ CARLOS
RODRÍGUEZ DE CASTRO, FELIPE CARLOS B. 		23-10-2020
DETERMINAR EL PAPEL QUE TIENEN LOS RECEPTORES NUCLEARES LXRa EN LA RESPUESTA INFLAMATORIA DEL MACROFAGO. DE LA ROSA MEDINA, JUAN VLADIMIR CASTRILLO VIGUERA, ANTONIO JESÚS
TABRAUE TARBAY, CARLOS 		22-09-2020
EVALUACIÓN FARMACOLÓGICA PRECLÍNICA DE NUEVOS PRODUCTOS BIOACTIVOS CON APLICACIONES COMO ANTITUMORALES MARTÍN RODRÍGUEZ, PATRICIA FERNÁNDEZ PÉREZ, LEANDRO FCO
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DÍAZ CHICO, JUAN CARLOS 		29-09-2017
POLIMORFISMOS DE LOS GENES FER Y FOXO3. PAPEL EN LA SUSCEPTIBILIDAD, GRAVEDAD Y PRONÓSTICO DE LA NEUMONÍA ADQUIRIDA EN LA COMUNIDAD VALENCIA GALLARDO, JOSÉ MANUEL RODRÍGUEZ DE CASTRO, FELIPE CARLOS B.
RODRÍGUEZ GALLEGO, JOSÉ CARLOS 		11-02-2016
EFECTO DE LOS POLIMORFISMOS DE LONGITUD DEL GEN DEL RECEPTOR DE ANDRÓGENOS (CAG)N Y (GGN)N SOBRE LA OSTEOPOROSIS PURRIÑOS GONZÁLEZ, ALBERTO OCTAVIO DÍAZ CHICO, BONIFACIO
SAAVEDRA SANTANA, PEDRO
SOSA HENRÍQUEZ, MANUEL JOSÉ 		10-02-2016
INMUNODEFICIENCIAS PRIMARIAS CAUSADAS POR DEFECTOS EN LA INMUNIDAD DEPENDIENTE DE LOS SISTEMAS (IL)-12/INTERFERON GAMMA (IFN-Y)e IL-23/ IL-17-IL-22 SOLOGUREN MARRERO, ITHAISA RODRÍGUEZ GALLEGO, JOSÉ CARLOS 10-02-2016
PAPEL DE LOS RECEPTORES FCGAMMA EN LA SUSCEPTIBILIDAD, GRAVEDAD Y PRONÓSTICO DE LA NEUMONÍA ADQUIRIDA EN LA COMUNIDAD MARCOS RAMOS, JOSÉ ALBERTO RODRÍGUEZ DE CASTRO, FELIPE CARLOS B.
RODRÍGUEZ GALLEGO, JOSÉ CARLOS 		10-02-2016
VARIANTES GENÉTICAS DE LA PROTEINA D DEL SURFACTANTE PULMONAR (SP-D): PAPEL EN LA SUSCEPTIBILIDAD Y GRAVEDAD LA INFECCIÓN POR VIRUS RESPIRATORIO SINCITIAL (VRS) PAVLOVIC NESIC, SVETLANA PEÑA QUINTANA, LUIS
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VALORACIÓN DE LOS CAMBIOS MORFOLÓGICOS Y PRONÓSTICOS RELACIONADOS CON LA MUTACIÓN BRAF EN EL CARCINOMA PAPILAR DE TIROIDES MARTÍNEZ MARTÍN, MARÍA SOLEDAD -
CABRERA GALVÁN, JUAN JOSÉ 		29-01-2016
INFLUENCIA GENÉTICA DE LAS PROTEÍNAS SURFACTANTES SP-A Y SP-D EN LA NEUMONÍA, LA GRIPE POR A (H1N1) 2009 Y EL ASMA ALÉRGICO HERRERA RAMOS, ESTEFANÍA DE LOS DOLORES RODRÍGUEZ GALLEGO, JOSÉ CARLOS
CARRILLO DÍAZ, TERESA
RODRÍGUEZ DE CASTRO, FELIPE CARLOS B. 		26-10-2015
"PAPEL DE LOS RECEPTORES LXR EN DIFERENCIACIÓN Y ESPECIALIZACIÓN DE MACRÓFAGOS" GUILLÉN SALGADO, JOSÉ ÁNGEL CASTRILLO VIGUERA, ANTONIO JESÚS
LÓPEZ BLANCO, FÉLIX
GALLARDO CAMPOS, GERMÁN 		30-06-2015
NEW INSIGHTS INTO SOCS2 ROLE IN HEPATIC METABOLISM. SANTANA FARRÉ, RUYMÁN FERNÁNDEZ PÉREZ, LEANDRO FCO 17-10-2014
STUDIES ON ESTRADIOL, GROWTH HORMONE AND SUPPRESSOR OF CYTOKINE SIGNALLING-2, AND THE INFLUENCE IN LIVER METABOLISM. DE MIRECKI GARRIDO, MERCEDES FERNÁNDEZ PÉREZ, LEANDRO FCO
GUERRA HERNÁNDEZ, CARLOS BORJA 		17-10-2014
CONTROL DE LA RESPUESTA INMUNO-INFLAMATORIA EN PULMÓN POR RECEPTORES LXR. HERNÁNDEZ HERNÁNDEZ, IRENE CASTRILLO VIGUERA, ANTONIO JESÚS
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TABRAUE TARBAY, CARLOS 		18-07-2014
INCIDENCIA DE LA SORDERA GENÉTICA EN FUERTEVENTURA EN LA POBLACIÓN DE 3 A 6 AÑOS. TRATAMIENTO Y SEGUIMIENTO. GARCÍA DE HOMBRE, ALINA MARÍA SANTANA RODRÍGUEZ, ALFREDO
RAMOS MACÍAS, ÁNGEL MANUEL
SAAVEDRA SANTANA, PEDRO
CABRERA GALVÁN, JUAN JOSÉ 		11-10-2013
Título Autor Director/es F.lectura
REGULACIÓN DE LA ACTIVIDAD AMPK EN MÚSCULO ESQUELÉTICO HUMANO POR RADICALES LIBRES DE E HIPOXIA. MORALES ÁLAMO, DAVID LÓPEZ CALBET, JOSÉ ANTONIO
GUERRA HERNÁNDEZ, CARLOS BORJA
DORADO GARCÍA, CECILIA 		19-12-2012
CARACTERIZACIÓN DE LA ACTIVIDAD DE LOS RECEPTORES NUCLEARES LXR EN LA ACTIVACIÓN Y MIGRACIÓN DE LAS CÉLULAS DENDRÍTICAS. BECEIRO CASAS, SUSANA CASTRILLO VIGUERA, ANTONIO JESÚS
LÓPEZ BLANCO, FÉLIX 		08-07-2011
ALTERACIONES GENÉTICAS Y EPIGENÉTICAS EN EL CÁNCER DE ENDOMETRIO. RAMÍREZ MORENO, RAQUEL DÍAZ CHICO, JUAN CARLOS
RODRÍGUEZ GONZÁLEZ, FRANCISCO GERMÁN
DÍAZ CHICO, BONIFACIO 		19-03-2011
EJERCICIO FÍSICO Y RECEPTOR MUSCULAR DE LEPTINA EN HUMANOS SANOS Y OBESOS. FUENTES NIETO, TERESA LÓPEZ CALBET, JOSÉ ANTONIO
GUERRA HERNÁNDEZ, CARLOS BORJA
SANTANA RODRÍGUEZ, ALFREDO 		16-03-2011
MICROSATÉLITES POLIMÓRFICOS: ESTUDIO DE SU POSIBLE PAPEL EN EL CÁNCER DE MAMA Y LA RESISTENCIA A LA INSULINA. GONZÁLEZ HERNÁNDEZ, ANA DÍAZ CHICO, BONIFACIO 18-02-2011
VALIDACIÓN DE LAS REGLAS DEL TOBILLO DE OTTAWA. REPERCUSIÓN EN LOS COSTES Y CALIDAD ASISTENCIAL. MARRERO BORDÓN, HONORIO DEL ROSARIO CABRERA GALVÁN, JUAN JOSÉ
SAAVEDRA SANTANA, PEDRO 		20-11-2010
VALORACIÓN DEL TRATAMIENTO CON SELLANTES BIOLÓGICOS Y TERAPIA CELULAR EN LA PREVENCIÓN DE LA FÍSTULA BRONCOPLEURAL EN UN MODELO EXPERIMENTAL IN VIVO. LLONTOP SANTISTEBAN, PEDRO ROLANDO -
FERNÁNDEZ PÉREZ, LEANDRO FCO 		19-07-2010
ESTUDIO DE LAS FUNCIONES HOMEOSTÁTICAS E INFLAMATORIAS DEL MACRÓFAGO. REGULACIÓN POR LOS RECEPTORES NUCLEARES LXR. ALONSO GONZÁLEZ, NOELIA CASTRILLO VIGUERA, ANTONIO JESÚS
LÓPEZ BLANCO, FÉLIX 		16-07-2010
EFECTOS DEL ENTRENAMIENTO DE FUERZA SOBRE LA SENSIBILIDAD DEL MÚSCULO ESQUELÉTICO HUMANO A LA LEPTINA. OLMEDILLAS FERNÁNDEZ, HUGO LÓPEZ CALBET, JOSÉ ANTONIO
GUERRA HERNÁNDEZ, CARLOS BORJA
SANTANA RODRÍGUEZ, ALFREDO
SANCHÍS MOYSI, JOAQUÍN 		09-03-2010
ESTUDIO DE LOS FACTORES QUE CONDICIONAN LOS RESULTADOS DE LA CIRUGÍA CONSERVADORA EN LA OSTEOMIELITIS DEL PIE DIABÉTICO. ARAGÓN SÁNCHEZ, FRANCISCO JAVIER CABRERA GALVÁN, JUAN JOSÉ 26-06-2009
UNA APROXIMACIÓN AL ESTUDIO MOLECULAR DEL RECHAZO CRÓNICO EN EL TRASPLANTE PULMONAR EXPERIMENTAL MEDIANTE LA TECNOLOGÍA DE DNA MICROARRAYS. GARCÍA HERRERA, RICARDO ALFONSO -
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MARTÍN BARRASA, JOSÉ LUIS
RODRÍGUEZ PÉREZ, JOSÉ CARLOS 		19-06-2009
ANDROGEN RECEPTOR GENE POLYMORPHISMS AND THEIR IMPLICATIONS ON HORMONE DEPENDENT TUMORS, METABOLIC DISORDERS AND PHYSICAL CONDITION. RODRÍGUEZ GONZÁLEZ, FRANCISCO GERMÁN DÍAZ CHICO, BONIFACIO
DÍAZ CHICO, JUAN CARLOS 		12-06-2009
INFLUENCIA DEL POLIMORFISMO DEL RECEPTOR DE ANDRÓGENOS EN LA MASA MUSCULAR Y LA MASA ÓSEA Y EN LA RESPUESTA HIPERTRÓFICA AL ENTRENAMIENTO DE FUERZA EN HOMBRES Y MUJERES. GUADALUPE GRAU, AMELIA LÓPEZ CALBET, JOSÉ ANTONIO
DORADO GARCÍA, CECILIA
GUERRA HERNÁNDEZ, CARLOS BORJA 		20-05-2009
EVALUACIÓN CLÍNICA DEL DOLOR TORÁCICO Y SU SEGUIMIENTO. EXPERIENCIA EN EL HOSPITAL GENERAL DE LANZAROTE. ANDUAGA AGUIRRE, MIREN ALOÑA CABRERA GALVÁN, JUAN JOSÉ 21-06-2008
NEFROPATÍA DIABÉTICA. INTERVENCIÓN DESDE ATENCIÓN PRIMARIA. GONZÁLEZ-MOHINO LORO, MARÍA BELÉN CABRERA GALVÁN, JUAN JOSÉ 21-06-2008
PAPEL DE LOS INHIBIDORES DE LA 3-HIDROXI-3-METILGLUTARIL COENZIMA A REDUCTASA (ESTATINAS) EN LÍNEAS CELULARES DE OSTEOSARCOMA. ESTUDIO IN VITRO. CABRERA BENÍTEZ, NURIA ESTHER GARCÍA CASTELLANO, JOSÉ MANUEL
FERNÁNDEZ PÉREZ, LEANDRO FCO 		20-06-2008
ESTUDIO DE LA FENALENONA COMO AGENTE FOTOSENSIBILIZADOR EN CÉLULAS PROMIELOCÍTICAS DERIVADAS DE LEUCEMIA HUMANA (HL-60): CARACTERIZACIÓN DE LAS VÍAS DE SEÑALIZACIÓN INTRACELULARES IMPLICADAS EN LA APOPTOSIS. SALMERÓN PEÑA, MARÍA LUISA GALLARDO CAMPOS, GERMÁN
TABRAUE TARBAY, CARLOS
LÓPEZ BLANCO, FÉLIX 		15-12-2006
INFLUENCIA DEL POLIMORFISMO TAQ 1B DE LA CETP SOBRE VARIABLES METABÓLICAS Y SU IMPLICACIÓN EN EL DESARROLLO DE LA DIABETES Y EL INFARTO DE MIOCARDIO LÓPEZ RÍOS, LAURA CHIRINO GODOY, RICARDO
NOVOA MOGOLLÓN, FRANCISCO
DÍAZ CHICO, JUAN CARLOS
DÍAZ CHICO, BONIFACIO 		28-10-2006
VALORACIÓN INMUNOHISTOQUÍMICA DE LA PROTEÍNA TPO, P53 Y KI67 EN PATOLOGÍA TIROIDEA. SANTANA SANTANA, JOSÉ RAMÓN CABRERA GALVÁN, JUAN JOSÉ
PÉREZ ALONSO, ESTEBAN
LIMIÑANA CAÑAL, JOSÉ MARÍA 		06-07-2006
ANÁLISIS DE PERFILES DE EXPRESIÓN GÉNICO HEPÁTICOS HORMONO- DEPENDIENTES: APLICACIÓN DE LA TECNOLOGÍA DE DNA MICROARRAYS. HENRÍQUEZ HERNÁNDEZ, LUIS ALBERTO FERNÁNDEZ PÉREZ, LEANDRO FCO 21-04-2006
Título Autor Director/es F.lectura
VALORACIÓN DE LAS PROTEÍNAS HSP27 Y HSP70 EN EL CARCINOMA DIFERENCIADO PAPILAR DE TIROIDES. MEDINA ORTEGA, CELIA BÁRBARA MARÍA DE LA CONCEPCIÓN CABRERA GALVÁN, JUAN JOSÉ
LIMIÑANA CAÑAL, JOSÉ MARÍA 		02-12-2004
EXPRESIÓN DE LA PROTEÍNA HSP27K EN LOS TUMORES ANEXIALES CUTÁNEOS. HERNÁNDEZ MACHÍN, BUENAVENTURA CABRERA GALVÁN, JUAN JOSÉ
BORREGO HERNANDO, LEOPOLDO 		17-07-2004
CARACTERIZACIÓN DE UN COMPLEJO MULTIMÉRICO PARA ESTEROIDES ANABOLIZANTES Y GLUCOCORTICOIDES (CMAG) EN RETÍCULO ENDOPLÁSMICO HEPÁTICO PÉREZ MACHÍN, RUBÉN FERNÁNDEZ PÉREZ, LEANDRO FCO
PÉREZ LUZARDO, OCTAVIO LUIS 		20-12-2002
ESTUDIO DE LAS PROTEINAS HSP27K, HSP70K Y FILAMENTOS INTERMEDIOS EN EL QUERATACONO AVANZADO MEDINA RIVERO, FRANCISCO JOSÉ CABRERA GALVÁN, JUAN JOSÉ
LIMIÑANA CAÑAL, JOSÉ MARÍA 		10-06-2002
REGULACIÓN DE LA BIOSÍNTESIS DE BIOPTERINAS POR CITOQUINAS, NEUROPÉPT. Y GIONADOTROFINAS EN CÉLULA GRANULOSA OVÁRICA: PAPEL DEL BH4 SOBRE LA PRODUCCIÓN DE ÓXIDO NÍTRICO, PROSTAGLANDINAS Y HORMONAS ESTEROIDEAS DÍAZ PEÑATE, RAQUEL GLORIA RUIZ GALARRETA HERNÁNDEZ, CARLOS MANUEL
TABRAUE TARBAY, CARLOS
GALLARDO CAMPOS, GERMÁN
LÓPEZ BLANCO, FÉLIX 		14-12-2001
REGULACIÓN DE LA ESTEROIDOGÉNESIS, EN CÉLULAS TUMORALES DE LEYDIG MA-10, POR EL FACTOR ACTIVADOR DE PLAQUETAS (PAF) JIMÉNEZ RAMÍREZ, JOSÉ JUAN LÓPEZ BLANCO, FÉLIX
RUIZ GALARRETA HERNÁNDEZ, CARLOS MANUEL 		23-06-2000
LUGAR DE UNIÓN PARA ESTANOZOLOL (LUES) EN RETÍCULO ENDOPLÁSMICO HEPÁTICO: CARACTERIZACIÓN COMO PROTEÍNA OLIGOMÉRICA INDUCIDA POR ESTRÓGENO. PÉREZ LUZARDO, OCTAVIO LUIS FERNÁNDEZ PÉREZ, LEANDRO FCO 15-11-1999
CAMBIOS MORFOLÓGICOS DENTOFACIALES SECUNDARIOS AL TRATA- MIENTO DE LA ESCOLIOSIS CON EL CORSE DE MILWAUKEE. CANDIA BOUSO, JOSÉ LUIS CABRERA GALVÁN, JUAN JOSÉ 29-06-1996
CARACTERIZACIÓN FARMACOLÓGICA DE UN LUGAR DE ALTA ESPECIFICIDAD PARA EL ESTEROIDE ANABOLIZANTE ESTANOZOLOL EN MICROSOMAS HEPÁTICOS. DOMÍNGUEZ BOADA, LUIS MARÍA FERNÁNDEZ PÉREZ, LEANDRO FCO 07-05-1994
Tipo Título Autor Director/es F.lectura
TFM IDENTIFICACIÓN Y EVALUACION PRECLÍNICA DE NUEVOS MODULADORES DEL RECEPTOR DE ESTRÓGENOS FERNÁNDEZ SANTANA, YERAY FERNÁNDEZ PÉREZ, LEANDRO FCO
RECIO CRUZ, CARLOTA PILAR 		30-07-2023
TFG PLAN DE CUIDADOS INDIVIDUALIZADO A PACIENTE CON HIPERTENSIÓN ARTERIAL SÁNCHEZ FARÍAS, ESTEBAN FERNÁNDEZ PÉREZ, LEANDRO FCO 27-07-2023
TFG EFICACIA DE LA COMBINACIÓN DE IVACAFTOR, TEZACAFTOR Y ELEXACAFTOR EN PACIENTES CON FIBROSIS QUÍSTICA GUERRA MEDINA, SARA FERNÁNDEZ PÉREZ, LEANDRO FCO 30-06-2023
TFG EL EFECTO DE LOS ALIMENTOS ULTRAPROCESADOS SOBRE EL ESTADO DE SALUD SÁNCHEZ PÉREZ, JULIA FERNÁNDEZ PÉREZ, LEANDRO FCO 30-06-2023
TFG NOVEDADES EN EL TRATAMIENTO DE LA DIABETES MELLITUS EN ADULTOS SANTANA RODRÍGUEZ, CAROLINA FERNÁNDEZ PÉREZ, LEANDRO FCO 30-06-2023
TFG CUIDADOS DE ENFERMERÍA AL PACIENTE CON EL SÍNDROME DE TAKO-TSUBO: EL GRAN DESCONOCIDO DE LAS PATOLOGÍAS CARDIACAS. MENCARA MORALES, JOEL TABRAUE TARBAY, CARLOS 29-06-2023
TFG PAPEL DE LA MUSICOTERAPIA COMO TERAPIA COMPLEMENTARIA EN EL CUIDADO ENFERMERO DE PACIENTES CON ENFERMEDADES NEURODEGENERATIVAS. RODRÍGUEZ DEL ROSARIO, PATRICIA TABRAUE TARBAY, CARLOS 29-06-2023
TFG TRABAJO DE INTERVENCIÓN PARA LA SALUD PARA PREVENIR LA PRÁCTICA DEL SEXTING. INTERVENCIÓN ENFERMERA SANTANO CABALLERO, YURENA LÓPEZ BLANCO, FÉLIX 27-06-2023
TFG EL AYUNO INTERMITENTE DESDE LA PERSPECTIVA ENFERMERA: BENEFICIOS PARA LA SALUD EN PACIENTES SANOS Y CON PATOLOGÍA ESTABLECIDA. RAMÍREZ MAILLO, CRISTIAN GUERRA HERNÁNDEZ, CARLOS BORJA 26-06-2023
TFG PAPEL DE LA ENFERMERA EN LA MEJORA DE LA ADHERENCIA TERAPÉUTICA EN EL ADULTO MAYOR POLIMEDICADO. FALCÓN LEÓN, SONIA GUERRA HERNÁNDEZ, CARLOS BORJA 26-06-2023
TFG PLAN DE CUIDADOS A UNA PACIENTE CON DIABETES MELLITUS TIPO 2 ABORDAJE DESDE ATENCIÓN PRIMARIA PEÑA NEGRÍN, IDAIRA DEL PINO LÓPEZ BLANCO, FÉLIX 27-07-2022
TFG REVISIÓN BIBLIOGRÁFICA DE LAS EVIDENCIAS CIENTÍFICAS QUE FUNDAMENTAN EL USO RACIONAL DE LAS VENDAS DE TRACCIÓN CORTA O BAJA ELASTICIDAD EN PACIENTES CON INSUFICIENCIA VENOSA EN ATENCIÓN PRIMARIA. GALVÁN GONZÁLEZ, ÁLVARO FERNÁNDEZ PÉREZ, LEANDRO FCO 27-07-2022
TFG REVISIÓN BIBLIOGRÁFICA DE LOS "PAE" ACTUALES EMPLEADOS EN EL CUIDADO DEL PIE DIABÉTICO LÓPEZ NARANJO, YAMILA FERNÁNDEZ PÉREZ, LEANDRO FCO 27-07-2022
TFG LA TERAPÉUTICA CON ANTICOAGULANTES ORALES: DESDE LOS ANTICOAGULANTES ORALES CLÁSICOS DICUMARÍNICOS HASTA LOS NUEVOS INHIBIDORES DIRECTOS DE LA TROMBINA DE LA GUARDIA YANES, DAYARA GUERRA HERNÁNDEZ, CARLOS BORJA 21-06-2022
TFG TRASPLANTES ALOGÉNICOS DE ÓRGANOS SÓLIDOS: ACTUALIZACIÓN DE LOS TRATAMIENTOS INMUNOSUPRESORES/INMUNOMODULARES MÁS EFICACES Y DE LOS CUIDADOS DE ENFERMERÍA MÁS APROPIADOS RODRÍGUEZ DÉNIZ, SAMUEL DE LA CRUZ GUERRA HERNÁNDEZ, CARLOS BORJA 21-06-2022
TFG ANÁLISIS PRELIMINAR DE UN MODELO EXPERIMENTAL TRANSGÉNICO (3xFLAG-LXRa) DE ORIGEN MURINO MEDIANTE TÉCNICAS DE INMUNOFLUORESCENCIA, EN EL CONTEXTO DEL ESTUDIO SOBRE EL PAPEL DEL RECEPTOR NUCLEAR LXRa EN LA MODULACIÓN DE LA RESPUESTA INMUNITARIA... PULIDO MAYOR, SHEILA TERESA TABRAUE TARBAY, CARLOS
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TFG CLAMPAJE ÓPTIMO DEL CORDÓN UMBILICAL HERNÁNDEZ DUQUE, YLENIA FLAVIA TABRAUE TARBAY, CARLOS 15-06-2022
TFG Factores que limitan el trabajo de la enfermería pediátrica en los cuidados paliativos oncológicos. CASTRO SENDINO, SARA TABRAUE TARBAY, CARLOS 15-06-2022
TFG TIMOMA Y TIMOMA CON INMUNODEFICIENCIA (SÍNDROME DE GOOD). VARIABILIDAD CLÍNICA E INMUNOLÓGICA Y PREDISPOSICIÓN A LA INFECCIÓN HERRERA HERRERA, SARAY CONCEPCIÓN CARRILLO DÍAZ, TERESA
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TFG PLAN DE CUIDADOS DE ENFERMERÍA A UN PACIENTE CON ENFERMEDAD PULMONAR OBSTRUCTIVA CRÓNICA GUTIÉRREZ URQUÍA, ACINTYA FERNÁNDEZ PÉREZ, LEANDRO FCO 10-06-2022
Tipo Título Autor Director/es F.lectura
TFG PROCESO DE ATENCIÓN DE ENFERMERÍA A UN PACIENTE CON DIABETES MELLITUS TIPO 2 SANTANA SANTANA, JOSÉ FRANCISCO LÓPEZ BLANCO, FÉLIX 30-07-2021
TFG LOS MACRÓFAGOS ASOCIADOS A TUMORES COMO DIANAS TERAPÉUTICAS EN ONCOLOGÍA DOMÍNGUEZ NUEZ, CARLOS ALBERTO TABRAUE TARBAY, CARLOS
DE LA ROSA MEDINA, JUAN VLADIMIR 		28-07-2021
TFG COMPLICACIONES CARDIOVASCULARES EN PACIENTES CON DIABETES MELLITUS Y SU ABORDAJE EN LOS CUIDADOS DE ENFERMERIA PÉREZ RODRÍGUEZ, DAVID HERNÁNDEZ GONZÁLEZ, INMACULADA SERVANDA
RECIO CRUZ, CARLOTA PILAR 		26-07-2021
TFM PAPEL DEL RECEPTOR NUCLEAR LXRA EN LA REGULACIÓN APIGENÉTICA DEL MACRÓFAGO EN LA INMUNIDAD INNATA: ANÁLISIS PRELIMINAR MEDIANTE ESTUDIOS DE INMUNO-PRECIPITACIÓN DE CROMATINA EN UN MODELO EXPERIMENTAL MURINO (CEPA C57/B16) QUE EXPRESA DE FORMA CONSTI NÚÑEZ ZUMALDE, UXUE TABRAUE TARBAY, CARLOS
CASTRILLO VIGUERA, ANTONIO JESÚS 		09-07-2021
TFG CUIDADOS ENFERMEROS AL PACIENTE PRÓXIMO A LA MUERTE. LÓPEZ HERNÁNDEZ, LILIANA GUERRA HERNÁNDEZ, CARLOS BORJA 14-06-2021
TFG INTERVENCIONES ENFERMERAS PARA UNA DESHABITUACIÓN TABÁQUICA EFICAZ. REVISIÓN BIBLIOGRÁFICA. YÁNEZ ESTUPIÑÁN, LAURA GUERRA HERNÁNDEZ, CARLOS BORJA 14-06-2021
TFG PROBIÓTICOS/SIMBIÓTICOS COMO ALTERNATIVA/COMPLEMENTO AL USO DE ANTIBIÓTICOS EN LA PREVENCIÓN Y TRATAMIENTO DE COMPLICACIONES TRAS CIRUGÍA INTRAABDOMINAL. REVISIÓN BIBLIOGRÁFICA PÉREZ PISABARRO, SARA GUERRA HERNÁNDEZ, CARLOS BORJA
BRITO CASILLAS, YERAY 		14-06-2021
TFM ESTRATEGIAS EN EL DESCUBRIMIENTO DE FÁRMACOS: DESDE EL CRIBADO FENOTÍPICO HASTAEL CRIBADO BASADO EN DIANAS MOLECULARES VEGA RODRÍGUEZ, ANGELO FERNÁNDEZ PÉREZ, LEANDRO FCO
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TFG IMPORTANCIA DE LAS TERAPIAS ASISTIDAS POR ANIMALES EN NIÑOS CON TEA PÉREZ QUINTERO, TARA IDAIRA ROMERO ALEMÁN, MARÍA DEL MAR 16-07-2020
TFG EL TRASTORNO DE ESTRÉS POSTRAUMÁTICO EN PERSONAL DE ENFERMERÍA TRAS ACCIDENTE CON RIESGO BIOLÓGICO, ¿CÓMO PREVENIR LOS ACCIDENTES CON RIESGO BIOLÓGICO? TRUJILLO SOSA, ALBA ISABEL GUERRA HERNÁNDEZ, CARLOS BORJA 25-06-2020
TFG MANEJO SEGURO DE FÁRMACOS CITOSTÁTICOS POR PARTE DEL PROFESIONAL DE ENFERMERÍA TORRES CAZORLA, VIRGINIA GUERRA HERNÁNDEZ, CARLOS BORJA 25-06-2020
TFG REPOSICIONAMIENTO DE LAS ESTATINAS EN CANCER ALMEIDA MORENO, ÓSCAR FERNÁNDEZ PÉREZ, LEANDRO FCO
GUERRA HERNÁNDEZ, CARLOS BORJA 		25-06-2020
TFG ESTUDIO DE LOS FACTORES PSICOSOCIALES QUE INTERVIENEN EN LOS CUIDADOS ENFERMEROS DE PACIENTES CON CÁNCER DE MAMA VIERA RAMÍREZ, MARÍA ISABEL TABRAUE TARBAY, CARLOS 19-06-2020
TFM REPOSICIONAMIENTO DE ESTATINAS EN LEUCEMIAS SÁNCHEZ GARCÍA, DAVID DE MIRECKI GARRIDO, MERCEDES
GUERRA HERNÁNDEZ, CARLOS BORJA 		21-06-2019
TFG EVALUACIÓN DE LA EFICACIA DEL EJERCICIO FÍSICO EN LOS PACIENTES ADULTOS CON ARTRITIS REUMATOIDE. REVISIÓN BIBLIOGRÁFICA RODRÍGUEZ DÁMASO, LUANA MARÍA GUERRA HERNÁNDEZ, CARLOS BORJA 13-06-2019
TFG INTERVENCIÓN EDUCATIVA COMUNITARIA EN NIÑOS DE 4ª DE PRIMARIA DE UN COLEGIO DE LAS PALMAS DE GRAN CANARIA PARA LA MEJORA DE LA HIGIENE BUCAL MORALES LUJÁN, ELIZABETH GUERRA HERNÁNDEZ, CARLOS BORJA 13-06-2019
TFG PAPEL DEL PROFESIONAL ENFERMERO EN LAS INTERVENCIONES EDUCATIVAS DIABETOLÓGICAS PARA LA PREVENCIÓN DE COMPLICACIONES RAMÍREZ MAILLO, JUAN ADONAY GUERRA HERNÁNDEZ, CARLOS BORJA 13-06-2019
TFG ESTUDIO DE LOS NODULOS TIROIDEOS CON CATEGORIA V DEL SISTEMA BETHESDA RAMOS PÉREZ, MARINA CABRERA GALVÁN, JUAN JOSÉ
NOVOA MOGOLLÓN, FRANCISCO 		14-06-2018
TFG INTERVENCIÓN EDUCATIVA SOBRE LA IMPORTANCIA DE UNA CORRECTA HIGIENE DEL SUEÑO EN LA SALUD, EL RENDIMIENTO ACADÉMICO Y PERSONAL EN UN GRUPO DE ADOLESCENTES DE 3º DE LA E.S.O. JIMÉNEZ CHODO, CRISTINA GUERRA HERNÁNDEZ, CARLOS BORJA 14-06-2018
TFG INTERVENCIÓN EDUCATIVA: ENSEÑANZA DE SOPORTE VITAL BÁSICO A ADOLESCENTES DE 4º DE LA ESO CASTILLO GUERRA, BELINDA GUERRA HERNÁNDEZ, CARLOS BORJA 14-06-2018
Tipo Título Autor Director/es F.lectura
TFG PAPEL DE LA NANOTECNOLOGIA EN LA REGENERACION DE LAS HERIDAS CUTANEAS: REVISION BIBLIOGRAFICA BOZA CORVO, DAVID JOSÉ ROMERO ALEMÁN, MARÍA DEL MAR
MONZÓN MAYOR, MAXIMINA 		13-06-2018
TFG TRANSICION A LA RESISTENCIA HORMONAL EN CANCER DE PROSTATA PEÑATE ALEMÁN, MOISÉS DÍAZ CHICO, BONIFACIO 13-06-2018
TFM BUSQUEDA DE NUEVAS MOLECULAS BIOACTIVAS CON INTERÉS EN CÁNCER Y ENFERMEDADES ENDOCRINAS: IDENTIFICACIÓN DE NUEVOS SERMS (Selective Estrogen Receptor Modulators) VALENCIA DAZA, NOEMÍ BELÉN FERNÁNDEZ PÉREZ, LEANDRO FCO
GUERRA HERNÁNDEZ, CARLOS BORJA 		27-07-2017
TFG MECHANISMS AND THERAPEUTIC ADVANCES IN ACUTE AND CHRONIC SPINAL COROD INJURIES RODRÍGUEZ VILLACIS, KEVIN JAVIER MONZÓN MAYOR, MAXIMINA
ROMERO ALEMÁN, MARÍA DEL MAR 		15-06-2017
TFG INTERVENCIÓN EDUCATIVA EN LA PREVENCIÓN DEL SÍNDROME DEL BURN. OUT GARCÍA DEL VALLE MAURI, LAURA GUERRA HERNÁNDEZ, CARLOS BORJA 12-06-2017
TFG INTERVENCIÓN EDUCATIVA PARA AUMENTAR LOS CONOCIMIENTOS SOBRE LOS EFECTOS NEGATIVOS QUE EL USO DEL TELÉFONO MÓVIL PUEDE TERNER EN LA SALUD DE LOS ADOLESCENTES DURÁN SILVA, ROSA MARÍA GUERRA HERNÁNDEZ, CARLOS BORJA 12-06-2017
TFG INTERVENCIÓN EDUCATIVA PARA LA PREVENCIÓN DE AGRESIONES EN EL ÁMBITO DE LA ATENCIÓN SANITARIA EN FUTUROS BOUCHKOUD , GHIZLANE GUERRA HERNÁNDEZ, CARLOS BORJA 12-06-2017
TFG INTERVENCIÓN EDUCATIVA PARA LA PREVENCIÓN DE LA DESIGUALDAD Y VIOLENCIA DE GÉNERO EN LAS PERSONAS ADOLESCENTES MARTEL MEDINA, CATHAYSA GUERRA HERNÁNDEZ, CARLOS BORJA 12-06-2017
TFG INTERVENICÓN EDUCATIVA: ALIMIENTACIÓN Y EJERCICIO FÍSICO EN ADOLESCENTES SANNAD SANNAD, IBTISAM MENDOZA DÍAZ, DAVID
GUERRA HERNÁNDEZ, CARLOS BORJA 		12-06-2017
TFG CHROMOSOMAL MICROARRAY ANALYSIS IN PEDIATRIC DIAGNOSIS MARCELO HERNÁNDEZ, DIEGO CABRERA GALVÁN, JUAN JOSÉ 26-07-2016
TFG INTERVENCIÓN EDUCATIVA EN LA PREVENCIÓN DEL CÁNCER DE PIEL BACHIR HEBILA, LAROSI GUERRA HERNÁNDEZ, CARLOS BORJA 26-07-2016
TFG PLAN DE CUIDADOS ENFERMERO INDIVIDUALIZADO "PACIENTE CON RIESGO CARDIOVASCULAR Y FACTORES DE RIESGO ASOCIADOS" DÍAZ MARTÍN, EDUARDO GUERRA HERNÁNDEZ, CARLOS BORJA
MEDINA ARTILES, EPIFANIA NATALIA 		26-07-2016
TFG PLAN DE CUIDADOS INDIVIDUALIZADO A UNA MUJER VÍCTIMA DE VIOLENCIA EN PAREJA CABRERA ALONSO, PAOLA GUERRA HERNÁNDEZ, CARLOS BORJA
MEDINA ARTILES, EPIFANIA NATALIA 		26-07-2016
TFG PLAN DE CUIDADOS INDIVIDUALIZADO A UNA PACIENTE CON EPILEPSIA GALLEGO FERNÁNDEZ, LIDIA GUERRA HERNÁNDEZ, CARLOS BORJA
MEDINA ARTILES, EPIFANIA NATALIA 		26-07-2016
TFG CÁNCER DE MAMA TRIPLE NEGATIVO: DIAGNÓSTICO MOLECULAR Y NUEVAS TERAPIAS MONEDERO AFONSO, JAIME DÍAZ CHICO, BONIFACIO 22-06-2016
TFG THE ROLE OF ANTI-NOGO-A IN RECOVERY AFTER STROKE GONZÁLEZ CÁCERES, ANA MARÍA MONZÓN MAYOR, MAXIMINA
ROMERO ALEMÁN, MARÍA DEL MAR 		22-06-2016
TFG INTERVENCIÓN EDUCATIVA: EJERCICIO FÍSICO Y BIENESTAR PSICOLÓGICO EN ADOLESCENTES PORTAZ AGÜERO, BÁRBARA AILÍN GUERRA HERNÁNDEZ, CARLOS BORJA 14-06-2016
TFG PLAN DE CUIDADOS PARA PACIENTES CON CARDIOPATÍA ISQUÉMICA EN UN PROGRAMA DE REHABILITACIÓN CARDIACA DOMICILIARIA MARTÍNEZ GUTIÉRREZ, ROBERTO RIVERO PERDOMO, JUDIT
GUERRA HERNÁNDEZ, CARLOS BORJA 		13-06-2016
TFG INTERVENCIÓN EDUCATIVA: ENSEÑANZA DE REANIMACIÓN CARDIOPULMONAR BÁSICA EN ADOLESCENTE DE 4º ESO EN UN INSTITUTO DE FUERTEVENTURA MEDINA DÍAZ, MIKEL JESÚS GUERRA HERNÁNDEZ, CARLOS BORJA 27-07-2015
TFG ACTITUD DE LAS ENFERMERAS HACIA EL USO DE LA METODOLOGÍA ENFERMERA Y VALIDACIÓN DEL CUESTIONARIO UTILIZADO PARA DETERMINARLA MEDINA ARTILES, EPIFANIA NATALIA GUERRA HERNÁNDEZ, CARLOS BORJA 15-06-2015
Tipo Título Autor Director/es F.lectura
TFG INTELIGENCIA EMOCIONAL EN ENFERMERÍA PERDOMO GÓMEZ, ÉSARA GUERRA HERNÁNDEZ, CARLOS BORJA
LIMIÑANA CAÑAL, JOSÉ MARÍA 		15-06-2015
TFG CALIDAD DEL DESAYUNO Y SU RELACIÓN CON EL RENDIMIENTO ACADÉMICO, FÍSICO Y EL ÍNDICE DE MASA CORPORAL EN UN GRUPO DE ADOLESCENTES MARTÍN SOLAR, MIRKA LIMIÑANA CAÑAL, JOSÉ MARÍA
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TFG CUIDADO DEL PACIENTE PEDIÁTRICO TRAQUEOTOMIZADO CARDONA GONZÁLEZ, YURENA GUERRA HERNÁNDEZ, CARLOS BORJA 18-06-2014
TFG INTERVENCIÓN EDUCATIVA SOBRE LA PROMOCIÓN DE CONOCIMIENTOS Y HÁBITOS SALUDABLES PARA LA VISIÓN EN NIÑOS/AS EN EDAD ESCOLAR ALEMÁN ARMAS, MÓNICA GUERRA HERNÁNDEZ, CARLOS BORJA 18-06-2014
TFG IMPORTANCIA DE LA INMUNIZACIÓN EN LA INFANCIA: MEJORA DE LA EDUCACIÓN SANITARIA A PADRES EN EL ÁMBITO CLÍNICO ASISTENCIAL SEGURA ALMEIDA, BELINDA GUERRA HERNÁNDEZ, CARLOS BORJA
MEDINA ARTILES, EPIFANIA NATALIA 		12-07-2013
TFG ¿SUFREN LOS ENFERMOS DE MEDICINA INTERNA DEL HOSPITAL DE FUERTEVENTURA QUEMAMIENTO POR EL TRABAJO? FERNÁNDEZ BENÍTEZ, JUAN LUIS GUERRA HERNÁNDEZ, CARLOS BORJA
MEDINA ARTILES, EPIFANIA NATALIA 		12-07-2013
TFG ALIMENTAMOS SUS CUERPOS Y SUS CONDUCTAS: INTERVENCIÓN COMUNITARIA GARCÍA PÉREZ, CARMEN YAIZA CASTELLANO OJEDA, M. ISABEL
GUERRA HERNÁNDEZ, CARLOS BORJA 		18-06-2013
TFG PROMOCIÓN DE HÁBITOS SALUDABLES PARA LA PROTECCIÓN DE LA PIEL ANTE LA EXPOSICIÓN SOLAR EN NIÑOS LÓPEZ CONCEPCIÓN, ANA MARÍA CASTELLANO OJEDA, M. ISABEL
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TFG PROPUESTA PARA EL ABORDAJE DE LA RESPUESTA HUMANA QUE DESENCADENA LA ENFERMEDAD INFLAMATORIA INTESTINAL RODRÍGUEZ DOMÍNGUEZ, HISSORA GUERRA HERNÁNDEZ, CARLOS BORJA 16-07-2012
Título Equipo investigador Importe Ámbito Tipo F.inicio F.fin
Proyecto de Investigación "Nanopolímeros Sintéticos y Naturales en el Proceso de Reinervación de Heridas Escisionales Cutáneas en Ratos, Modelo Experimental de Cicatrización Humana Por Segunda Intención. Parte Ii: Análisis Estadístico de Resultados y Tramitación de Patentes" ROMERO ALEMÁN MARÍA DEL MAR (IP)
HERNÁNDEZ RODRÍGUEZ JOSÉ ENRIQUE
MARTÍN BARRASA JOSÉ LUIS
MONZÓN MAYOR MAXIMINA
PÉREZ GALVÁN JOSÉ MANUEL
ZAMBRANO CONTIÑAS SUSANA		 16000 Autonómico Proyecto mediante convenio 01/12/2017 30/03/2019
CONVENIO ENTRE LA UNIVERSIDAD DE LAS PALMAS DE GRAN CANARIA Y LA FUNDACIÓN CANARIA PARQUE CIENTÍFICO TECNOLÓGICO DE LA UNIVERSIDAD DE LAS PALMAS DE GRAN CANARIA PARA LA GESTIÓN DE LA PLATAFORMA ULPGenomiC DE ANÁLISIS Y REPOSITORIO DE DATOS MOLECULARES. GARCÍA JIMÉNEZ M. DEL PILAR (IP)
AFONSO LÓPEZ JUAN MANUEL
BENÍTEZ DÍAZ DOMINGO JUAN
FERNÁNDEZ PÉREZ LEANDRO FCO
GONZÁLEZ HENRÍQUEZ MARÍA NIEVES
MÉNDEZ RODRÍGUEZ JUAN ÁNGEL
PESTANO BRITO JOSÉ JUAN
ROBAINA ROMERO RAFAEL JUAN
SOSA HENRÍQUEZ PEDRO ANTONIO		 3560 Autonómico Convenio-Contrato 15/03/2017 31/03/2017
¿Nanopolímeros sintéticos y naturales en el proceso de reinervación de heridas escisionales cutáneas en ratones: Modelo experimental de cicatrización humana por segunda intención¿ ROMERO ALEMÁN MARÍA DEL MAR (IP)
HERNÁNDEZ RODRÍGUEZ JOSÉ ENRIQUE
MARTÍN BARRASA JOSÉ LUIS
MONZÓN MAYOR MAXIMINA
PÉREZ GALVÁN JOSÉ MANUEL
ZAMBRANO CONTIÑAS SUSANA		 16000 Autonómico Convenio-Contrato 30/11/2016 30/11/2017
Alteración De La Actividad De LXR En Macrófagos Durante La Inflamación GARCÍA ARENCIBIA MOISÉS (IP)
CASTRILLO VIGUERA ANTONIO JESÚS
DE LA ROSA MEDINA JUAN VLADIMIR
LÓPEZ BLANCO FÉLIX		 6000 Autonómico Proyecto De Convocatoria Pública Competitiva 01/01/2016 31/12/2017
Nanopolímeros sintéticos y naturales (Aloe Vera y miel) en el proceso de reinervación de la piel de ratón HERNÁNDEZ RODRÍGUEZ JOSÉ ENRIQUE (IP)
ROMERO ALEMÁN MARÍA DEL MAR		 4500 Local Proyecto De Convocatoria Pública Competitiva 06/11/2014 05/11/2016
Estudios Anamapatológicos CABRERA GALVÁN JUAN JOSÉ (IP) 128812.51 Local Convenio-Contrato 26/10/2009 25/10/2017
Contratacion de Personal Investigador Por Centros de Investigacion Cientifica y Desarrollo Tecnologico Para 2003 (Programa Ramon y Cajal) CASTRILLO VIGUERA ANTONIO JESÚS (IP) 328712 Nacional Proyecto De Convocatoria Pública Competitiva 17/11/2004 16/11/2009
Nº solicitud Título Inventores Fecha concesión
201600173 Nanofibras de aloe vera Monzón Mayor, Maximina
Romero Alemán, María Del Mar		 28/03/2017
18173213.2 Hybrid Honey Nanofibers Hernández Rodríguez, José Enrique
Monzón Mayor, Maximina
Perez Galvan, Jose Manuel
Romero Alemán, María Del Mar		 11/07/2018
PCT/ES2017/000029 Hybrid Aloe Vera Nanofibres Hernández Rodríguez, José Enrique
Monzón Mayor,Maximina
Pérez Galván, José Manuel
Romero Alemán, María Del Mar		 14/09/2017
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Apellidos, nombre Convocatoria Organismo financiador Responsable Año convocatoria
RODRIGO GONZÁLEZ, LAURA 2014-3 PTC GRUPOS Universidad Las Palmas de Gran Canaria FERNÁNDEZ PÉREZ, LEANDRO FCO 2014
JIMÉNEZ MONZÓN, ROBERTO 2010 PTC Universidad Las Palmas de Gran Canaria FERNÁNDEZ PÉREZ, LEANDRO FCO 2010
MARTÍN RODRÍGUEZ, PATRICIA PREDOCTORAL Universidad Las Palmas de Gran Canaria FERNÁNDEZ PÉREZ, LEANDRO FCO 2013
GUERRA RODRÍGUEZ, MIGUEL ALFONSO PREDOCTORAL Ministerio Educación, Cultura y Deporte FERNÁNDEZ PÉREZ, LEANDRO FCO 2016
DE MIRECKI GARRIDO, MERCEDES POSTDOCTORAL Universidad Las Palmas de Gran Canaria FERNÁNDEZ PÉREZ, LEANDRO FCO 2016
GARCÍA ARENCIBIA, MOISÉS POSTDOCTORAL Universidad Las Palmas de Gran Canaria LÓPEZ BLANCO, FÉLIX 2013
HERRERA RAMOS, ESTEFANIA DOLORES POSGRADO Universidad Las Palmas de Gran Canaria RODRÍGUEZ DE CASTRO, FELIPE CARLOS B. / RODRÍGUEZ GALLEGO, JOSÉ CARLOS 2009
BECEIRO CASAS, SUSANA POSGRADO Ministerio Ciencia e Innovación CASTRILLO VIGUERA, ANTONIO JESÚS / CASTRILLO VIGUERA, ANTONIO JESÚS 2006
DE MIRECKI GARRIDO, MERCEDES POSGRADO Universidad Las Palmas de Gran Canaria FERNÁNDEZ PÉREZ, LEANDRO FCO 2008
SANTANA VIERA, SERGIO Posdoctoral 2020 Universidad Las Palmas de Gran Canaria FERNÁNDEZ PÉREZ, LEANDRO FCO 2020
HERNÁNDEZ BARAZA, LUISA PIF 2021-2022 Universidad Las Palmas de Gran Canaria GUERRA HERNÁNDEZ, CARLOS BORJA 2021
RECIO CRUZ, CARLOTA PILAR JUAN DE LA CIERVA-INCORPORACIÓN Ministerio Economía y Empresa FERNÁNDEZ PÉREZ, LEANDRO FCO 2018
RECIO CRUZ, CARLOTA PILAR JUAN DE LA CIERVA-FORMACIÓN Ministerio Economía y Empresa FERNÁNDEZ PÉREZ, LEANDRO FCO 2016
RECIO CRUZ, CARLOTA PILAR Convocatoria extraordinaria 2022 para la contratación de Doctores/as de prestigio del Programa Viera y Clavijo Universidad Las Palmas de Gran Canaria FERNÁNDEZ PÉREZ, LEANDRO FCO 2022
Productividad Variable P=137,14 (corte=86,95). Variable S=57 (corte=72,7). Clasificación GIR: A+
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